The four-volume set LNAI 6881-LNAI 6884 constitutes the refereed proceedings of the 15th International Conference on Knowledge-Based Intelligent Information and Engineering Systems, KES 2011, held in Kaiserslautern, Germany, in September 2011. Part 4: The total of 244 high-quality papers presented were carefully reviewed and selected from numerous submissions. The 46 papers of Part 4 are organized in topical sections on human activity support in knowledge society, knowledge-based interface systems, model-based computing for innovative engineering, document analysis and knowledge science, immunity-based systems, natural language visualisation advances in theory and application of hybrid intelligent systems.