This book constitutes revised selected papers from the 13th International Workshop on Constructive Side-Channel Analysis and Secure Design, COSADE 2022, held in Leuven, Belgium, in April 2022. The 12 full papers presented in this volume were carefully reviewed and selected from 25 submissions. The papers cover the following subjects: implementation attacks, secure implementation, implementation attack-resilient architectures and schemes, secure design and evaluation, practical attacks, test platforms, and open benchmarks.