This book constitutes the refereed proceedings of the 10th International Conference on Information Systems Security, ICISS 2014, held in Hyderabad, India, in December 2014. The 20 revised full papers and 5 short papers presented together with 3 invited papers were carefully reviewed and selected from 129 submissions. The papers address the following topics: security inferences; security policies; security user interfaces; security attacks; malware detection; forensics; and location based security services.