This book constitutes the proceedings of the 41st International Conference on Computer Safety, Reliability and Security, SAFECOMP 2022, which took place in Munich, Germany, in September 2022. The 24 full papers included in this volume were carefully reviewed and selected from 93 submissions. SafeComp has contributed to the progress of the state-of-the-art in dependable application of computers in safety-related and safety-critical systems. SafeComp is an annual event covering the state-of-the-art, experience and new trends in the areas of safety, security and reliability of critical computer applications.