This book constitutes the proceedings of the 21st International Conference on Computer Information Systems and Industrial Management Applications, CISIM 2022, held in Barranquilla, Colombia, in July 2022.  The 28 papers presented together with 3 keynotes were carefully reviewed and selected from 68 submissions. The main topics covered by the chapters in this book are biometrics, security systems, multimedia, classification and clustering, and industrial management as well as interesting papers on computer information systems as applied to wireless networks, computer graphics, and intelligent systems.