This book constitutes the proceedings of the 23rd International Conference on Verification, Model Checking, and Abstract Interpretation, VMCAI 2022, which took place in Philadelphia, PA, USA, in January 2022. The 22 papers presented in this volume were carefully reviewed from 48 submissions. VMCAI provides a forum for researchers working on verification, model checking, and abstract interpretation and facilitates interaction, cross-fertilization, and advancement of hybrid methods that combine these and related areas.