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The Zebrafish: Disease Models and Chemical Screens de H. William Detrich III

The Zebrafish: Disease Models and Chemical Screens: Methods in Cell Biology, cartea 138

H. William Detrich III, Leonard Zon, Monte Westerfield
en Limba Engleză Hardback – 27 ian 2017
The Zebrafish: Genetics, Genomics, and Transcriptomics, Fourth Edition, is the latest volume in the Methods in Cell Biology series that looks at methods for the analysis of genetics, genomics, and transcriptomics of Zebrafish.
Chapters cover such topics as gene-trap mutagenesis, genetic Screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, and developmental epigenetics and the zebrafish interactome.


  • Covers sections on model systems and functional studies, imaging-based approaches, and emerging studies
  • Presents chapters written by experts in the field
  • Contains cutting-edge material on the topic
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Specificații

ISBN-13: 9780128034736
ISBN-10: 0128034734
Pagini: 746
Dimensiuni: 191 x 235 x 35 mm
Greutate: 1.48 kg
Ediția:4
Editura: ELSEVIER SCIENCE
Seria Methods in Cell Biology

Cuprins

Part I: Adipose Tissue1. In vivo imaging and quantification of regional adiposity in zebrafish
Part II: Innate and Adaptive Immune Systems2. Innate immune cells and bacterial infection in zebrafish3. Best practices for germ-free derivation and gnotobiotic zebrafish husbandry4. Infectious disease models in zebrafish5. Live imaging the earliest host innate immune response to preneoplastic cells using a zebrafish inducible KalTA4-ERT2/UAS system6. Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells
Part III: Blood and Lymph7. Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis8. Studying disorders of vertebrate iron and heme metabolism using zebrafish9. The lymphatic vasculature revisited—new developments in the zebrafish
Part IV: Visceral Organs10. Modeling intestinal disorders using zebrafish11. Analysis of pancreatic disease in zebrafish
Part V: Musculoskeletal System12. Using the zebrafish to understand tendon development and repair13. Small teleost fish provide new insights into human skeletal diseases14. Muscular dystrophy modeling in zebrafish
Part VI: Central and Sensory Nervous Systems15. Analysis of myelinated axon formation in zebrafish16. Zebrafish models of human eye and inner ear diseases
Part VII: Cancer17. A zebrafish xenograft model for studying human cancer stem cells in distant metastasis and therapy response18. Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling19. Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma20. Zebrafish models of leukemia21. Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain
Part VIII: Transplantation22. Transplantation in zebrafish
Part IX: Chemical Screening23. Chemical screening in zebrafish for novel biological and therapeutic discovery

Recenzii

Praise for the Series:
"The series is invaluable for workers at all levels of cell biology." --Nature