This book constitutes the proceedings of the 16th International Conference on Tests and Proofs, TAP 2022, which was held as part of Software Technologies: Applications and Foundations, STAF 2022, and took place in Nantes, France in July 2022. The 6 full papers together with 1 invited extended abstract included in this volume were carefully reviewed and selected from 11 submissions. They were organized in topical sections on formal analysis, and proofs, and effective testing.