This book constitutes the refereed conference proceedings of the 29th International Colloquium on Structural Information and Communication Complexity, SIROCCO 2022, held in Paderborn, Germany, in June 2022. The 16 full papers presented in this book were carefully reviewed and selected from 30 submissions. SIROCCO is devoted to the study of the interplay between structural knowledge, communication, and computing in decentralized systems of multiple communicating entities. Special emphasis is given to innovative approaches leading to better understanding of the relationship between computing and communication.