This two-volume set constitutes the refereed proceedings of the 52nd Euromicro Conference on Software Engineering and Advanced Applications, SEAA 2026, held in Kraków, Poland, during September 2–4, 2026. The 50 full papers and 22 short papers were carefully reviewed and selected from 146 submissions.These papers were organized in the following topical sections: Part I: Cyber-Physical Systems; Data and AI Driven Engineering; Model-Driven Engineering and Modeling Languages; Emerging Computing Technologies; Practical Aspects of Software Engineering; Explainable and Trustworthy Applications. Part II: Model-Driven Engineering and Modeling Languages; Software Management: Measurement, Peopleware, and Innovation; Systematic Literature Reviews and Mapping Studies in Software Engineering; Software Process and Product Improvement; Software Analytics: Mining Software Open Datasets and Repositories.