This book constitutes the refereed proceedings of the 13th International Conference on Progress in Cryptology in Africa, AFRICACRYPT 2022, held in Fes, Morocco, from July 18th - 20th, 2022.  The 25 papers presented in this book were carefully reviewed and selected from 68 submissions. The papers are organized in topical sections on symmetric cryptography; attribute and identity based encryption; symmetric cryptanalysis; post-quantum cryptography; post-quantum (crypt)analysis; side-channel attacks; protocols and foundations; public key (crypt) analysis.