This book constitutes the refereed proceedings of the 16th International Conference on Intelligent Computer Mathematics, CICM 2023, held in Cambridge, UK, in September 2023. The 14 full papers, 2 project/survey papers, 6 short papers, and 1 tool paper presented were carefully reviewed and selected from a total of 37 submissions. The papers focus on advances in formalization, automatic theorem proving and learning, search and classification, teaching and geometric reasoning, and logic and systems, among other topics.