Thanks to scientific and technological advances in many parallel fields, medical procedures are rapidly evolving towards solutions which are less invasive and more effective. In the previous decades, information processing in diagnostic imaging provided many solutions to physicians in particular within radiology, neurology, cardiology, nuclear medicine and radiation therapy departments. In the last decade, progress in computer technology, imaging and mechatronics has allowed computer-assisted intervention (CAI) systems and solutions to penetrate the intervention and operating rooms. CAI’s major challenge in the beginning of the twenty-first century is real-time processing, analysis and visualization of large amount of heterogeneous, static and dynamic patient data, and understanding of surgery for designing intelligent operating rooms and developing advanced training tools. Excellent scientists, engineers and physicians have created many advanced research groups around the world and are starting to provide innovative, breakthrough solutions. Information Processing in Computer-Assisted Interventions (IPCAI) aims at gathering the best work in this field and allowing authors to present and discuss it in detail. IPCAI wishes to select and present the highlights of research in CAI and aims at distinguishing itself for the quality of the presented papers and the excitement and depth of the discussions they generate.