This book constitutes the proceedings of the 22nd International Conference on Formal Engineering Methods, ICFEM 2020, held in Singapore, Singapore, in March 2021. The 16 full and 4 short papers presented together with 1 doctoral symposium paper in this volume were carefully reviewed and selected from 41 submissions. The papers cover theory and applications in formal engineering methods together with case studies. They also represent the recent development in the use and development of formal engineering methods for software and system development.