This book constitutes the proceedings of the 22st International Conference on Embedded Computer Systems: Architectures, Modeling, and Simulation, SAMOS 2021, which took place in July 2022 in Samos, Greece. The 11 full papers and 7 short papers presented in this volume were carefully reviewed and selected from 45 submissions. The conference covers a wide range of  embedded systems design aspects, including machine learning accelerators, and power management and programmable dataflow systems.