This book constitutes the proceedings of the 18th IFIP International Conference on Distributed Applications and Interoperable Systems, DAIS 2018, held in Madrid, Spain, in June 2018. The 10 papers presented together with 2 short papers in this volume were carefully reviewed and selected from 33 submissions. The papers are organized in topical sections on application domains, including stream processing, video dissemination, storage, privacy protection, and large-scale orchestration.