This book constitutes the proceedings of the 8th International Symposium on Dependable Software Engineering, SETTA 2022, held in Beijing, China, in October 2022. The 11 full papers and 3 short papers in this volume were carefully reviewed and selected from 29 submissions, and are presented with 3 abstracts of keynote speeches. They deal with latest research results and ideas on bridging the gap between formal methods and software engineering.