This book constitutes the refereed proceedings of the 25th International Conference on Applications of Evolutionary Computation, EvoApplications 2022, held as part of Evo*2022, in April 2022, co-located with the Evo*2022 events EuroGP, EvoCOP, and EvoMUSART.  
The 46 revised full papers presented in this book were carefully reviewed and selected from 67 submissions.