This book constitutes the thoroughly refereed post-conference proceedings of the Second International Symposium on Intelligent Informatics (ISI 2013) held in Mysore, India during August 23-24, 2013. The 47 revised papers presented were carefully reviewed and selected from 126 initial submissions. The papers are organized in topical sections on pattern recognition, signal and image processing; data mining, clustering and intelligent information systems; multi agent systems; and computer networks and distributed systems. The book is directed to the researchers and scientists engaged in various fields of intelligent informatics.