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Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function: Methods in Molecular Biology, cartea 1265

Editat de Volkmar Weissig, Marvin Edeas
en Limba Engleză Hardback – 30 ian 2015
This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.
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Specificații

ISBN-13: 9781493922871
ISBN-10: 1493922874
Pagini: 476
Ilustrații: XXIII, 447 p. 124 illus., 65 illus. in color.
Dimensiuni: 178 x 254 x 32 mm
Greutate: 1.04 kg
Ediția:2015
Editura: Springer
Colecția Humana
Seria Methods in Molecular Biology

Locul publicării:New York, NY, United States

Public țintă

Professional/practitioner

Cuprins

1. DQAsomes as the Prototype of Mitochondria-targeted Pharmaceutical Nanocarriers: Preparation, Characterization, and Use
            Volkmar Weissig
 2. Predicting Mitochondrial Targeting by Small Molecule Xenobiotics Within Living Cells Using QSAR Models
            Richard W. Horobin
 3. Targeting Mitochondria with Small Molecules: The Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide
            Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, and Richard C. Hartley
 4. Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes
            Parul Benein, Mohammed Almuteri, Ahmed Mehanna, and Gerard G.M. D’Souza
 5. Synthesis and Evaluation of 18F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging
            Dong-Yeon Kim and Jung-Joon Min
 6. Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria
            José Teixeira, Pedro Soares, Sofia Benfeito, Michael P Murphy, Paulo J. Oliveira, and Fernanda Borges
 7. Mitochondriotropic Nano-Emulsified Genistein-Loaded Vehicles for Cancer Therapy
            Jimmy Pham, Oliver Grundmann, and Tamer Elbayoumi
 8. Formulation and Optimization of Mitochondria-Targeted Polymeric Nanoparticles
            Sean Marrache, Rakesh K. Pathak, and Shanta Dhar
 9. Ex Vivo Generation of Functional Immune Cells by Mitochondria-Targeted Photosensitization of Cancer Cells
            Sean Marrache, Smanla Tundup, Donald A. Harn, and Shanta Dhar
 10. Targeting the Mitochondrial Genome Via a Dual Function MITO-Porter: Evaluation of mtDNA-Levels and Mitochondrial Function
            Yuma Yamada and Hideyoshi Harashima
 11. Mitochondrial, Acidic, and Cytosolic pHs Determination by 31P NMR Spectroscopy: Design of New Sensitive Targeted pH Probes
            Marcel Culcasi, Sophie Thétiot-Laurent, Ariane Atteia, and Sylvia Pietri
 12. Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related Research
            Mikhail Y. Vyssokikh, Yury N. Antonenko, Konstantin G. Lyamzaev, Tatyana I. Rokitskaya, and Vladimir P. Skulachev
 13. Synthesis and Testing of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin
            Lucia Biasutto, Andrea Mattarei, and Cristina Paradisi
 14. Evaluation of Respiration of Mitochondria in Cancer Cells Exposed to Mitochondria-Targeted Agents
            Katarina Kluckova, Lan-Feng Dong, Martina Bajzikova, Jakub Rohlena, and Jiri Neuzil
 15. The Effect of Mitochondrially Targeted Anti-Cancer Agents on Mitochondrial (Super)Complexes
Magdalena Vondrusova, Ayanachew Bezawork-Geleta, Karishma Sachaphibulkij, Jaroslav Truksa, and Jiri Neuzil
 16. Mitochondrial Targeting of Recombinant RNA
            Ilya Dovydenko, Anne-Marie Heckel, Yann Tonin, Ali Gowher, Alya Venyaminova, Ivan Tarassov, and Nina Entelis
 17. Mitochondrial Targeting of Catalytic RNAs
            Daria Mileshina, Adnan Khan Niazi, Eliza Wyszko, Maciej Szymanski, Romain Val, Clarisse Valentin, Jan Barciszewski, and André Dietrich
 18. Allotopic Expression of ATP6 in the Mouse as a Transgenic Model of Mitochondrial Disease
            David A. Dunn and Carl A. Pinkert
 19. Analysis of Pollutant-Induced Changes in Mitochondrial DNA Methylation
            Hyang-Min Byun and Timothy M. Barrow
 20. ETS and DEAS Studies of the Reduction of Xenobiotics in Mitochondrial Intermembrane Space
            Stanislav A. Pshenichnyuk and Alberto Modelli
 21. Analysis of Mitochondrial Morphology and Function Under Conditions of Mitofusin 2 Deficiency
            Juan Pablo Muñoz and Antonio Zorzano
 22. Yeast as a Tool to Study Mitochondrial Retrograde Pathway En Route to Cell Stress Response
            Maša Ždralević, Nicoletta Guaragnella and Sergio Giannattasio
 23. Cell Energy Budget Platform for Assessment of Cell Metabolism
            Dmitri B. Papkovsky and Alexander V. Zhdanov
 24. Induced Pluripotent Stem Cells (iPSCs) for Modeling Mitochondrial DNA Disorders
            Alessandro Prigione
 25. Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice
            Thomas Kolbe, Ralf Steinborn, and Joerg P. Burgstaller
 26. In Vivo Visualization and Quantification of Mitochondrial Morphology in C. elegans
            Reuben L. Smith, Winnok H. De Vos, Richard de Boer, Erik M.M. Manders, and Hans van der Spek
 27. Mitochondrial DNA as a Biosensor of UV Exposure in Human Skin
            Amy Bowman and Mark A. Birch-Machin
 28. Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation
            Matthias Hecker, Natascha Sommer, and Konstantin Mayer
 29. Atomic Force Microscopy-Based Shape Analysis of Heart Mitochondria
            Gi-Ja Lee and Hun-Kuk Park
 30. Enzymatic Assays for Probing Mitochondrial Apoptosis
            Zhenyu Wang, Claire Nicolas, Rodolphe Fischmeister, and Catherine Brenner
 31. A Cybrid Cell Model for the Assessment of the Link Between Mitochondrial Deficits and Sporadic Parkinson’s Disease
            Daniela M. Arduíno, A. Raquel Esteves, Russell H. Swerdlow, and Sandra M. Cardoso
 32. Analysis of Mitochondrial Network by Imaging: Proof of Technique in Schizophrenia
            Dorit Ben-Shachar, Edith Suss-Toby, and Odile Robicsek

Textul de pe ultima copertă

This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Methods and Protocols, Volume II: Manipulating Mitochondrial Function describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Mitochondrial Medicine: Methods and Protocols provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.

Caracteristici

Includes cutting-edge methods and protocols for the manipulation of mitochondrial function
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts