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Hypoxia: From Genes to the Bedside: Advances in Experimental Medicine and Biology, cartea 502

Editat de Robert C. Roach, Peter D. Wagner, Peter H. Hackett
en Limba Engleză Hardback – 31 ian 2002
Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia.
Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.
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Specificații

ISBN-13: 9780306466960
ISBN-10: 0306466961
Pagini: 445
Ilustrații: XV, 445 p.
Dimensiuni: 178 x 254 x 25 mm
Greutate: 1.02 kg
Ediția:2002
Editura: Springer Us
Colecția Springer
Seria Advances in Experimental Medicine and Biology

Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

Tribute to John T. Reeves.- 1. John T. Reeves, MD.- From Genes to the Bedside.- 2. Genetic lessons from high altitude.- 3. Genes, environment, and exercise.- 4. Skeletal muscle angiogenesis.- 5. Leukocyte-endothelial interactions in environmental hypoxia.- Training at Altitude for Sea Level Performance.- 6. Hypoxia training for sea-level performance.- 7. The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise.- High Altitude Pulmonary Edema.- 8. Update: High altitude pulmonary edema.- Comparative Biology.- 9. Phylogenetic comparison and artificial selection.- 10. Genetic and environmental adaptation in high altitude natives.- 11. Common themes of adaptation to hypoxia.- Erythropoietin.- 12. Biology of erythropoietin.- 13. Lessons to better understanding of hypoxia sensing.- 14. Erythropoietin use and abuse.- Mountain Medicine.- 15. Mountaineering in thin air.- 16. Weight loss at high altitude.- Stress Proteins and Hypoxia.- 17. The heme oxygenase system and cellular defense mechanisms.- 18. Hypoxia-inducible factor in brain.- Transepithelial Sodium Transport.- 19. Proton-gated cation channels — neuronal acid sensors in the central and peripheral nervous system.- 20. Structure function relationships of ENaC and its role in sodium handling.- 21. Transepithelial sodium and water transport in the lung.- Advances in Cardiorespiratory Control in Hypoxia.- 22. Is ventilatory acclimatization to hypoxia a phenomenon that arises through mechanisms that have an intrinsic role in the regulation of ventilation at sea level?.- 23. Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia.- 24. The pVHL-HIF-1 system.- Frontiers in Hypoxia Research.- 25. Interval hypoxic training.- 26. Gene transfer andmetabolic modulators as new therapies for pulmonary hypertension.- 27. Chronic mountain sickness.- 28. International Working Group for Chronic Mountain Sickness.- 29. Late and Amended Abstracts.

Notă biografică

Dr. Robert Roach is the Director of the Altitude Research Center at the University of Colorado. He specializes in the study of physiological adaptations by humans to high altitude, with a recent emphasis on the genomic responses to allow humans to thrive in hypoxia. 

Dr. Peter Wagner is a Distinguished Professor of Medicine and Bioengineering at the University of California, San Diego. His research addresses the theoretical and experimental basis of oxygen transport and its limitations in the lungs and skeletal muscles in health and disease. 

Dr. Peter Hackett is a world-renowned high altitude expert and altitude research pioneer. He is a leading authority on altitude illness, high altitude climbing, wilderness medicine, and the effects of altitude on people living and working in the mountains.

Textul de pe ultima copertă

The latest in a series of books from the International Hypoxia Symposia,this volume spans reviews on key topics in hypoxia, and abstracts from posterand oral presentations. The biannual International Hypoxia Symposia arededicated to hosting the best basic scientific and clinical minds to focus onthe integrative and translational biology of hypoxia. Long before‘translational medicine’ was a catchphrase, the founders of the InternationalHypoxia Symposia brought together basic scientists, clinicians andphysiologists to live, eat, ski, innovate and collaborate in the CanadianRockies.
This collection of reviews and abstracts is divided into six sections,each covering new and important work relevant to a broad range of researchersinterested in how humans adjust to hypoxia, whether on the top of Mt. Everestor in the pulmonary or cardiology clinic at low altitude. The sections include:

  • Epigenetic Variations in Hypoxia
  • High Altitude Adaptation
  • Hypoxia and Sleep
  • Hypoxia and the Brain
  • Molecular Oxygen Sensing
  • Physiological Responses to Hypoxia
Dr. Robert Roach is the Director of the Altitude Research Center at theUniversity of Colorado. He specializes in the study of physiologicaladaptations by humans to high altitude, with a recent emphasis on the genomic responsesto allow humans to thrive in hypoxia. 
Dr. Peter Wagner is a Distinguished Professorof Medicine and Bioengineering at the University of California, San Diego. Hisresearch addresses the theoretical and experimental basis of oxygen transportand its limitations in the lungs and skeletal muscles in health and disease. 
Dr. Peter Hackett is a world-renowned high altitude expert and altituderesearch pioneer. He is a leading authority on altitude illness, high altitudeclimbing, wilderness medicine, and the effects of altitude on people living andworking in the mountains.


Caracteristici

Discusses the latest up-to-date research and discoveries related to hypoxia Spans reviews on key topics in hypoxia Covers findings revealed at the latest International Hypoxia Symposia Includes supplementary material: sn.pub/extras