Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease: Advances in Experimental Medicine and Biology, cartea 517

1. Introduction.- Dopamine and Parkinson’s Disease.- Experimental Models of Parkinsonism in Laboratory Animals.- Graft-Assisted Neural Reconstruction (“Brainware Engineering”?).- References.- 2. Biology And Pathology of the Weaver Mutant Mouse.- Cellular and Molecular Genetics of the Weaver Mutation.- Alterations of the Mesotelencephalic Dopamine Projection System.- Cerebellar Phenotype of the Weaver Mutant.- Hippocampal Morphology.- Biology of Normal ? Mutant Cell Associations.- Behavioral Phenotype.- Structural Clues to the Weaver Riddle.- References.- 3. Histochemical Properties of Intrastriatal Mesencephalic Grafts.- Methodological Considerations.- Expression of Catecholaminergic Neurotransmitter-Related Molecules and Quantitative Aspects of Dopaminergic Neuron Survival.- Comparative Survival of Dopaminergic Neurons in Grafts Placed in Weaver and in 6-OHDA Lesion Hosts.- Expression of Neuropeptides and Structural Proteins.- References.- 4. Structural Correlates of Process Outgrowth and Circuit Reconstruction.- Axonal Reinnervation of the Host Striatum.- Synaptic Investment of Graft-Derived Dopamine Terminals.- Compartmental Specificity of the Striatal Reinnervation.- Innervation of Nonstriatal Regions by the Grafts.- Chemoaffinity and Axon-Target Recognition in Development and in Transplantation.- Dendrite Extension from the Graft into the Host Striatum.- Expression of Molecules Related to Axonal and Dendritic Outgrowth.- References.- 5. Neurochemical Indices of Functional Restoration.- Dopamine Uptake Markers.- Autoradiography of [3H]Dopamine Uptake.- Dopamine Receptors.- Neurotensin Receptors.- Excitatory and Inhibitory Amino Acid Receptors.- References.- 6. Behavioral Recovery of Functional Responses.- Unilateral Grafts and Circling Behavior.- Correlationof Turning Bias with Structural and Biochemical Parameters.- Dissociation of the Functional Contribution of Graft-Derived Axons and Dendrites in Rotational Asymmetry.- Enhancement of Motor Performance after Bilateral Transplantation.- References.- 7. Directions for Future Research.- Analysis of Early Events in Graft-Host Interactions.- Trophic Considerations.- Neurotransmitter Mechanisms.- Supplemental Restoration of the Interrupted Nigro-Striato-Nigral Loop by Striatal/Nigral Double Grafts.- References.