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Clinical Epidemiology: Practice and Methods: Methods in Molecular Biology, cartea 1281

Editat de Patrick S. Parfrey, Brendan J. Barrett
en Limba Engleză Paperback – 8 oct 2016
Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.
Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.
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Specificații

ISBN-13: 9781493955770
ISBN-10: 1493955772
Pagini: 533
Ilustrații: XIII, 533 p. 52 illus., 7 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 0 kg
Ediția:Softcover reprint of the original 2nd ed. 2015
Editura: Springer
Colecția Humana
Seria Methods in Molecular Biology

Locul publicării:New York, NY, United States

Cuprins

Part I: Introduction
 
1. On Framing the Research Question and Choosing the Appropriate Research Design
            Patrick S. Parfrey and Pietro Ravani
 
2. Research Ethics for Clinical Researchers
            John D. Harnett and Richard Neuman
 
3. Definitions of Bias in Clinical Research
            Geoffrey Warden
 
Part II: Longitudinal Studies
 
4. Longitudinal Studies 1: Determination of Risk
            Sean W. Murphy
 
5. Longitudinal Studies 2: Modeling Data Using Multivariate Analysis
            Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey
 
6. Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions
            Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey
 
7. Longitudinal Studies 4: Matching Strategies to Evaluate Risk
            Matthew T. James
 
8. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease
            Navdeep Tangri and Claudio Rigatto
 
Part III: Randomized Controlled Clinical Trials
 
9. Randomized Controlled Trials 1: Design
            Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey
 
10. Randomized Controlled Trials 2: Analysis
            Robert N. Foley
 
11. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes
            Michelle M. Richardson, Megan E. Grobert, and Klemens B. Meyer
 
12. Randomized Controlled Trials 4: Biomarkers and Surrogate Outcomes
            Claudio Rigatto and Brendan J. Barrett
 
13. Randomized Controlled Trials 5: Determining the Sample Size and Power for Clinical Trials and Cohort Studies
            Tom Greene
 
14. Randomized Controlled Trials 6: On Contamination and Estimating the Actual Treatment Effect
            Patrick S. Parfrey
 
15. Randomized Controlled Trials 7: Analysis and Interpretation of Quality of Life Scores
            Robert N. Foley and Patrick S. Parfrey
 
16. Randomized Controlled Trials 8: Planning, Monitoring, and Execution
            Elizabeth Hatfield, Elizabeth Dicks, and Patrick S. Parfrey
 
Part IV: The Basics for Other Clinical Epidemiology Methods
 
17. Evaluation of Diagnostic Tests
            John M. Fardy and Brendan J. Barrett
 
18. Qualitative Research in Clinical Epidemiology
            Deborah M. Gregory and Christine Y. Way
 
19. Health Economics in Clinical Research
            Braden J. Manns
 
Part V: Clinical Genetic Research
 
20. Clinical Genetic Research 1: Bias
            Susan Stuckless and Patrick S. Parfrey
 
21. Clinical Genetic Research 2:  Genetic Epidemiology of Complex Phenotypes
            Darren D. O’Rielly and Proton Rahman
 
22. Clinical Genetic Research 3: Genetics ELSI (Ethical, Legal and Social Issues) Research
            Daryl Pullman and Holly Etchegary
 
Part VI: Methods in Evidence–Based Decision Making
 
23. Evidence-Based Decision Making 1: Critical Appraisal
            Laurie K. Twells
 
24. Evidence-Based Decision Making 2: Systematic Reviews and Meta-Analysis
            Aminu Bello, Natasha Wiebe, Amit Garg, and Marcello Tonelli
 
25. Evidence-Based Decision Making 3: Health Technology Assessment
            Daria O’Reilly, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree
 
26. Evidence-Based Decision Making 4: Development and Limitations of Clinical Practice Guidelines
            Bruce Culleton
 
27. Evidence-Based Decision-Making 5: Translational Research
            Deborah M. Gregory and Laurie K. Twells
 
28. Evidence-Based Decision Making 6: Utilization of Administrative Databases for Health Services Research
            Turin Chowdury and Brenda Hemmelgarn
 
29. Evidence-Based Decision Making 7: Knowledge Translation
            Braden J. Manns
 
30. Evidence-Based Decision Making 8: Health Policy, A Primer for Researchers
            Victor Maddalena

Textul de pe ultima copertă

Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.
Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.

Caracteristici

Includes cutting-edge techniques involving clinical research
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
Includes supplementary material: sn.pub/extras