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Carbohydrate Chemistry

Carbohydrate Chemistry


en Limba Engleză Hardback – 11 dec 1998

Adresat studenților la masterat, cercetătorilor din biochimie și practicienilor din industria farmaceutică, acest volum oferă o sinteză riguroasă a progreselor recente în chimia zaharidelor. Carbohydrate Chemistry, ajuns la numărul 40 în prestigioasa serie Specialist Periodical Reports a Royal Society Of Chemistry, demonstrează rolul critic al gliconștiințelor în progresul societății contemporane. Observăm o structură densă, de 670 de pagini, care acoperă atât fundamentul teoretic al sintezei, cât și aplicațiile practice în biologie. Remarcăm modul în care editorii Amelia Pilar Rauter, Thisbe K. Lindhorst și Yves Queneau au selectat contribuțiile pentru a evidenția convergența dintre chimia organică și biologia moleculară. Lucrarea extinde cadrul propus de Recent Trends in Carbohydrate Chemistry cu date noi din perioada recentă, punând un accent mai mare pe inovația sistemică și pe impactul social al noilor descoperiri. Apreciem rigoarea metodologică și actualitatea surselor citate, volumul servind drept o arhivă critică a stadiului actual al cercetării, similară ca profunzime cu seria Advances in Carbohydrate Chemistry and Biochemistry, dar cu o orientare specifică spre abordările chimico-biologice integrate. Textul în limba engleză este tehnic, fiind esențial pentru cei care urmăresc ultimele metodologii de laborator și tendințele în designul glicoconjugaților.

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Specificații

ISBN-13: 9780854042180
ISBN-10: 0854042180
Pagini: 456
Dimensiuni: 140 x 216 x 29 mm
Greutate: 0.73 kg
Ediția:Edition.

De ce să citești această carte

Cercetătorii și studenții avansați beneficiază de o imagine de ansamblu asupra celor mai noi strategii de sinteză și analiză în gliconștiințe. Cartea oferă acces la expertiza colectivă a unor lideri în domeniu, fiind un instrument de referință pentru documentarea proiectelor de cercetare biomedicală și dezvoltare tehnologică, unde carbohidrații joacă un rol central în inovație.

Despre autor

Amelia Pilar Rauter este o personalitate proeminentă în chimia carbohidraților, profesor la Universitatea din Lisabona și editor experimentat pentru publicații de prestigiu ale Royal Society of Chemistry. Alături de Thisbe K. Lindhorst, specialistă în chimie organică la Universitatea din Kiel, și Yves Queneau, director de cercetare la CNRS în Lyon, aceștia formează o echipă editorială cu o vastă experiență internațională. Expertiza lor combinată acoperă sinteza organică, glicobiologia și aplicațiile industriale, asigurând o selecție riguroasă a materialelor științifice publicate în seria Specialist Periodical Reports.

Descriere scurtă

Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Cuprins

1. Applications of glycobiology: biological and immunological effects of a chemically modified amylose-derivative; 2. Lipopolysaccharide structure and biological activity of Cystic fibrosis pathogens; 3. Synthesis of inner core lipopolysaccharide structures for the development of vaccines and antibiotics against Gram-negative bacterial infections; 4. Synthetic Glycopeptides in Vaccine Development and Antibody Epitope Mapping; 5. Posttranslational sialylation and its impact on leukocyte recruitment during inflammation; 6. Glycoengineering of protein-based therapeutics; 7. Exploring CDG diagnostic tools; 8. Bladder cancer: glycosylation insights; 9. Levansucrases of Pseudomonas bacteria: novel approaches for protein expression, assay of enzymes, fructooligosaccharides and heterooligofructans; 10. Recent advances on the application of NMR methods to study the conformation, dynamics and molecular recognition features of carbohydrates; 11. Glycosidase inhibitors: versatile tools in glycobiology; 12. An overview of key routes for the transformation of sugars into carbasugars and related compounds; 13. Multivalent glycoconjugates in Medicinal Chemistry; 14. Glycotransporters for gene delivery; 15. Furanose-based templates in the chemoselective generation of molecular diversity; 16. Synthesis of carbohydrate-based artificial siderophores and their biological applications; 17. Smart biomaterials: the contribution of glycoscience

Notă biografică

Dr Yves Queneau, Research Director at CNRS, is Head of the Organic and Bioorganic Chemistry Laboratory at INSA Lyon, Deputy-Director of the "Institut de Chimie et Biochimie Moleculaires et Supramoleculaires" (ICBMS), University of Lyon, France and Honorary Professor at the University of Hull, UK. After his doctorate on aqueous Diels-Alder reactions involving glycodienes under the supervision of Professor Andre Lubineau (Orsay, 1988) he was appointed as CNRS fellow and worked on cycloaddition reactions towards complex sugars. He then spent one year in 1992 in Professor Samuel J. Danishefsky's group in Memorial Sloan Kettering Cancer Center in New York, USA. He later moved to Lyon in a mixed CNRS-industrial research facility dedicated to sucrose chemistry (1995-2003) before joining its present position where he develops his research in organic and biological chemistry with a particular interest for the use of carbohydrates as renewable raw materials.

Textul de pe ultima copertă

In this volume, glycochemistry and glycobiology have been combined to demonstrate the contribution of organic chemistry, modern analytics, biological and biochemical expertise to the increasingly important field of glycomics. A polysaccharide immunomodulator with therapeutic implications, carbohydrate vaccines, new findings emphasizing the influence of carbohydrate decoration on the regulation of inflammatory response and new therapeutic approaches in the treatment of acute and chronic inflammatory diseases, recent progress on glycoengineering based on a glycosylation strategy to optimize protein drugs, congenital disorders of glycosylation, and key aspects of the glycosylation changes associated with bladder cancer are amongst the subjects presented in this volume. The contribution of glycochemistry to innovation in glycosciences is shown with chapters covering highly functionalized exo-glycals for the generation of molecular diversity in a chemoselective manner, imino sugar glycosidase inhibitors, carbasugars, multivalent glycoconjugates, including glycodendrimers, glyconanotubes, and glyconanoparticles, and their uses in medicinal chemistry, as well as artificial saccharide-based and saccharide-functionalized gene delivery systems. Siderophores based on monosaccharides (which have proven effective for Gram-negative bacteria and mycobacteria), and the so-called smart materials, (which can modulate and control cell behaviour), complete the volume. Volume 38 of Carbohydrate Chemistry - Chemical and Biological Approaches contains contributions ranging from glycochemistry to glycobiology. This collection demonstrates in a meaningful way how the interdisciplinary approach of an international glyconetwork can advance the field of carbohydrate research in Europe and worldwide.