Tumor Microenvironment: The Main Driver of Metabolic Adaptation de Jacinta Serpa

Tumor Microenvironment: The Main Driver of Metabolic Adaptation: Advances in Experimental Medicine and Biology, cartea 1219

Editat de Jacinta Serpa

en Limba Engleză Hardback – 5 mar 2020

Publicată sub egida Springer în cadrul seriei Advances in Experimental Medicine and Biology, prima ediție a volumului Tumor Microenvironment marchează o schimbare de paradigmă în oncologia moleculară, concentrându-se pe adaptarea metabolică drept principal motor al supraviețuirii tumorale. Putem afirma că această lucrare depășește simpla descriere a geneticii cancerului, oferind o analiză clinică a modului în care celulele maligne își reciclează relațiile interspecifice pentru a asigura biomasa necesară proliferării. Suntem de părere că noutatea absolută a acestui volum constă în integrarea microbiotei și a adipocitelor ca parteneri biologici activi în dinamica metabolică a tumorii.

Structura editorială este riguros împărțită în două secțiuni fundamentale. Prima secțiune analizează presiunea selectivă a microenvironmentului, incluzând protocoale actualizate privind rolul lactatului în efectul Warburg și implicarea celulelor endoteliale și a macrofagelor. A doua secțiune se concentrează pe semnalizarea metabolică, detaliind modul în care plasticitatea celulară este orchestrată prin căi precum semnalizarea Wnt.

Acest manual de referință este comparabil cu The Heterogeneity of Cancer Metabolism de Anne Le, însă Tumor Microenvironment se distinge prin accentul pus pe interacțiunea cu microorganismele simbiotice și pe modelele de privare de nutrienți. Dacă titluri precum Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions oferă o privire de ansamblu, volumul editat de Jacinta Serpa oferă o perspectivă tehnică aprofundată asupra reprogramării metabolice ca barieră în calea răspunsului la tratament medicamentos.

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Specificații

ISBN-13: 9783030340247
ISBN-10: 3030340244
Pagini: 443
Ilustrații: VII, 443 p. 1 illus.
Dimensiuni: 178 x 254 mm
Greutate: 0.95 kg
Ediția:1st ed. 2020
Editura: Springer International Publishing
Colecția Springer
Seria Advances in Experimental Medicine and Biology

Locul publicării:Cham, Switzerland

De ce să citești această carte

Această resursă este esențială pentru oncologi și cercetători care doresc să înțeleagă de ce terapiile standard eșuează în fața plasticității metabolice. Cititorul câștigă o viziune integrată asupra modului în care tumorile exploatează resursele de energie ale gazdei, de la adipocite la microbiota intestinală, oferind baze teoretice solide pentru dezvoltarea unor strategii terapeutice care să țintească nu doar celula canceroasă, ci întregul său sistem de suport metabolic.

Despre autor

Jacinta Serpa este o autoritate recunoscută în domeniul oncobiologiei, activând ca editor pentru această ediție sub egida Springer. Expertiza sa se concentrează pe studiul metabolismului tumoral și al interacțiunilor complexe din microenvironmentul canceros. Prin coordonarea acestui volum în cadrul seriei Advances in Experimental Medicine and Biology, Serpa reunește contribuții multidisciplinare care reflectă cele mai recente descoperiri în biochimia și fiziopatologia cancerului, consolidând legătura dintre cercetarea fundamentală și aplicațiile clinice în oncologie.

Descriere scurtă

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. Themetabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book.
The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

Cuprins

Preface.- Tumor microenvironment a job of several holders.- Tumor microenvironment- a selective pressure boosting cancer.- Lactate and lactate transporters as key players in the maintenance of the Warburg effect.- Section 1. Adaptive metabolic features are sustained by tumor microenvironment.- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis.- Gut microbiota and cancer of the host: colliding interests.- Metabolic plasticity of tumor cells: how they do adapt to food deprivation.- Multifaceted oncogenic role of adipocytes in the tumour microenvironment.- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology.- Monocytes and macrophages in cancer: unsuspected roles.- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression.- Microenvironment driven metabolic adaptation in melanoma.- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis.- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt.- The bone marrow niche - the tumor microenvironment that ensures leukemia progression.- Section 3. Metabolic fitness and therapy response in cancer.- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer.- The metabolic remodelling in lung cancer and its putative consequence in therapy response.- Hydrogen sulfide metabolism and signaling in the tumor microenvironment.- Using metabolic adaptation to design new drugs.- Metabolomics- a new way of screening cancer.- NMR as a tool for metabolomics.- Section 5. Animal models- addressing cancer microenvironment.- Animal models to study cancer and its microenvironment.- Modulating the metabolic phenotype of cancer microenvironment.- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae.- Section 6. In vitroand ex vivo cancer models.- In vitro and ex vivo models- the tumor microenvironment in a flask.- Index.

Notă biografică

Jacinta Serpa is an Assistant Professor and Senior Researcher at the Universidade Nova de Lisboa.

Textul de pe ultima copertă

This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance.This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new playersto be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented.
This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.

Caracteristici

An integrative view of tumor microenvironment and cancer metabolic adaptations, focusing different cancer contexts and interspecific cellular actions A wide range of traits, showing the way cancer adapts metabolically to the microenvironment A clear presentation of different cancer models and analytical techniques, their usefulness, advantages and limitations