Radiation Proteomics de Dariusz Leszczynski

Radiation Proteomics: Advances in Experimental Medicine and Biology, cartea 990

Editat de Dariusz Leszczynski

en Limba Engleză Hardback – 3 feb 2013

FARMACOLOGIA și terapeutica modernă depind critic de înțelegerea mecanismelor moleculare declanșate de stimuli externi, iar Radiation Proteomics investighează tocmai aceste răspunsuri la nivel de proteine sub influența radiațiilor. Notăm cu interes modul în care această lucrare, editată de Dariusz Leszczynski, încearcă să accelereze adoptarea proteomicii în biologia radiațiilor, un domeniu unde tehnicile de înaltă rezoluție au pătruns mai lent decât în cercetarea biomedicală generală. Considerăm că structura volumului este una riguroasă, debutând cu principiile de bază ale spectrometriei de masă și direcțiile tehnologice emergente, pentru a trece apoi la aplicații clinice și experimentale specifice. Analiza se extinde dincolo de radiațiile ionizante clasice, acoperind subiecte de actualitate precum impactul câmpurilor electromagnetice modulate prin radiofrecvență și al radiațiilor ultraviolete asupra celulelor cutanate. Un punct forte al lucrării este explorarea proteomului urinar și plasmatic ca instrument de diagnostic și predicție (biodozimetrie) în patologia indusă de radiații. Această abordare completează volumul Biomolecular Action of Ionizing Radiation de Shirley Lehnert cu o perspectivă axată strict pe dinamica proteinelor, oferind date concrete despre modul în care micromediul tumoral este alterat în timpul tratamentului radiologic. Dacă lucrările anterioare se concentrau pe daunele ADN-ului, volumul de față mută accentul pe expresia globală a proteinelor și pe căile de semnalizare celulară, oferind o imagine de ansamblu asupra stresului celular indus de radiații.

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Specificații

ISBN-13: 9789400758957
ISBN-10: 9400758952
Pagini: 140
Ilustrații: VII, 130 p. 14 illus., 9 illus. in color.
Dimensiuni: 183 x 260 x 13 mm
Greutate: 0.48 kg
Ediția:2013
Editura: Springer
Colecția Advances in Experimental Medicine and Biology
Seria Advances in Experimental Medicine and Biology

Locul publicării:Dordrecht, Netherlands

Public țintă

Research

De ce să citești această carte

Această resursă este esențială pentru cercetătorii din radiobiologie și fizică medicală care doresc să integreze metodele proteomice în studiul efectelor radiațiilor. Cititorul câștigă o înțelegere profundă a biomarkerilor proteici utilizați în biodozimetrie și diagnostic. Este o lectură specializată care fundamentează teoretic utilizarea spectrometriei de masă pentru evaluarea riscurilor de mediu și optimizarea radioterapiei prin monitorizarea micromediului tumoral.

Descriere scurtă

Methods of proteomics have been shown to be powerful tools in search of target proteins – proteins that respond in cells to an internal or an external stimulus. Proteomics is widely used in biomedical research. However, in radiation biology research, following exposures of living matter to low doses of either ionizing or non-ionizing radiation, proteomics approach is only very slowly gaining support. This book, by presenting the current status of the use of proteomics in radiation biology, will help to attract attention to the field of radiation proteomics.

Cuprins

Mass spectrometry-based proteomics: Basic principles and emerging technologies and directions.- Ionizing radiation effects on cells, organelles and tissues on proteome level.- Radiation treatment effects on the proteome of the tumour microenvironment.- Serum and plasma proteomics and its possible use as detector and predictor of radiation diseases.- The Urine Proteome as a Radiation Biodosimeter.- Effects of radiofrequency-modulated electromagnetic fields on proteome.- Global protein expression in response to extremely low frequency magnetic fields.- Ultraviolet radiation effects on the proteome of skin cells.- Effects of ultraviolet radiation on skin cell proteome.

Textul de pe ultima copertă

Proteomics is widely used in search of biomarkers, pharmacology, clinical research and toxicology. With the help of proteomics large amount of information about the physiology of living cells can be obtained in a single experiment. Combining this information with data from genomics and other high-throughput screening techniques like transcriptomics and metabolomics allows gaining new insights into physiology of life and diseases.
The area of research that is still waiting for the proteomics “boom” is the search for the biological effects of radiation. It is relatively much known about the effects of high doses of radiation, both ionizing and non-ionizing. However, much less is known about the effects of low or very low doses of radiation, to which people are often exposed in their every day life. The effects of the low doses of ionizing radiation (e.g. bystander effect) or low doses of non-ionizing radiation (e.g. effect of radiation emitted by wireless communication devices)are not yet reliably established. Often these effects are small and difficult to discover and to replicate. One of the limiting factors in the research of low dose radiation effects is often the lack of the knowledge of the cellular target molecules.
Proteomics, the high-throughput screening of expression and activity of proteins is very well suited for the research aiming at discovery of molecular targets of low dose radiation. Proteomics approach seems to be particularly well suited for studying biological effects of low dose radiation because it might reveal effects that are not possible to predict based on the presently available knowledge concerning the effects of the high doses of radiation.
Search through the published scientific literature shows that to date was published only a very limited number of proteomics studies examining effects of radiation. This book, Radiation Proteomics, presents the current status the research of radiation effects using proteomics approach. The book begins with the review of current status and the future direction in the development of proteomics methods. This is followed by chapters dealing with the effects of ionizing and non-ionizing radiation on cells, tissues and body fluids. The editor of the book, Research Professor Dariusz Leszczynski, is known for studies that introduced, some 10 years ago, the high-throughput screening techniques of proteomics and transcriptomics into the main stream of the research on the biological effects of the non-ionizing radiation emitted by the wireless communication devices. In recent years he has also done studies examining effects of low-dose ionizing radiation on cellular proteome.

Caracteristici

Up to date review of proteomics studies examining radiation effects on cells and tissues Included both ionizing and non-ionizing radiation effects Review of low-dose ionizing radiation effects Review of therapeutic doses of ionizing radiation effects and search for biomarkers of response/damage Non-ionizing radiation chapters deal with ELF-EMF, RF-EMF and UV