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Organ Tissue Engineering de Daniel Eberli

Organ Tissue Engineering: Reference Series in Biomedical Engineering

Editat de Daniel Eberli, Sang Jin Lee, Andreas Traweger
en Limba Engleză Hardback – 22 apr 2021

Ne-a atras atenția modul în care Organ Tissue Engineering abordează scenariile clinice critice provocate de deficitul de organe pentru transplant, propunând o metodologie riguroasă pentru generarea de substitute biologice. Subliniem faptul că, deși înțelegerea fenotipurilor celulare a avansat considerabil, volumul recunoaște onest dificultatea tehnică de a replica arhitectura complexă a unui organ întreg. Reținem abordarea pragmatică, pas cu pas, necesară pentru a trece de la simple culturi celulare la constructe tisulare gata pentru implantare care să poată augmenta funcția fiziologică.

Structura editorială este una de referință, fiind organizată pe sisteme de organe: de la ingineria țesutului cerebral și a retinei, până la soluții complexe pentru plămâni, ficat și pancreas. Fiecare capitol debutează cu o prezentare succintă a modificărilor fiziopatologice și a necesității clinice actuale, urmată de o analiză detaliată a biomaterialelor și a surselor celulare. Această lucrare reprezintă o evoluție firească în opera editorului Daniel Eberli, care, spre deosebire de volumul său anterior Cells and Biomaterials in Regenerative Medicine — axat pe obstacolele generale ale domeniului —, se concentrează aici pe rezultate funcționale bine definite și pe soluționarea blocajelor specifice fiecărui organ.

În contextul literaturii de specialitate, considerăm volumul o alternativă la Introduction to Tissue Engineering – Applications and Challenges de R. Birla pentru rezidenți și cercetători, având avantajul unei organizări mult mai granulare pe segmente anatomice specifice (precum sistemul olfactiv sau aparatul dentar). Față de abordările teoretice, Organ Tissue Engineering pune accent pe „readouts” funcționali, oferind o perspectivă clinică imediată asupra modului în care implanturile se integrează și evoluează in vivo.

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Specificații

ISBN-13: 9783030442101
ISBN-10: 3030442101
Pagini: 600
Ilustrații: XVI, 600 p. 61 illus., 55 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 1.13 kg
Ediția:1st ed. 2021
Editura: Springer International Publishing
Colecția Springer
Seriile Reference Series in Biomedical Engineering, Tissue Engineering and Regeneration

Locul publicării:Cham, Switzerland

De ce să citești această carte

Această resursă este esențială pentru specialiștii în inginerie biomedicală și medicina regenerativă care caută o sinteză actualizată a soluțiilor pentru înlocuirea organelor. Cititorul câștigă o înțelegere profundă a interacțiunii dintre celule și biomateriale, aplicată pe cazuri concrete. Este un instrument de lucru indispensabil pentru a identifica rapid stadiul traducerii clinice și blocajele tehnologice în dezvoltarea grefelor funcționale.

Despre autor

Daniel Eberli este un expert recunoscut în domeniul urologiei și al medicinei regenerative, activând ca editor și autor pentru numeroase publicații de prestigiu sub egida Springer. Experiența sa clinică, reflectată în lucrări precum Basiswissen Urologie, este dublată de o activitate intensă de cercetare în ingineria tisulară. Împreună cu Sang Jin Lee și Andreas Traweger, Eberli coordonează proiecte care vizează utilizarea celulelor stem și a biomaterialelor inovatoare pentru a depăși barierele actuale în regenerarea organelor, consolidându-și poziția de lider de opinie în seriile de referință dedicate bioingineriei.

Descriere scurtă

The notion of being able to engineer complete organs has inspired an entire generation of researchers. While recent years have brought significant progress in regenerative medicine and tissue engineering, the immense challenges encountered when trying to engineer an entire organ have to be acknowledged. Despite a good understanding of cell phenotypes, cellular niches and cell-to-biomaterial interactions, the formation of tissues composed of multiple cells remains highly challenging. Only a step-by-step approach will allow the future production of a living tissue construct ready for implantation and to augment organ function.
In this book, expert authors present the current state of this approach. It offers a concise overview and serves as a great starting point for anyone interested in the application of tissue engineering or regenerative medicine for organ engineering. Each chapter contains a short overview including physiological and pathological changes as well as the current clinical need. The potential cell sources and suitable biomaterials for each organ type are discussed and possibilities to produce organ-like structures are illustrated. The ultimate goal is for the generated small tissues to unfold their full potential in vivo and to serve as a native tissue equivalent. By integrating and evolving, these implants will form functional tissue in-vivo. This book discusses the desired outcome by focusing on well-defined functional readouts. Each chapter addresses the status of clinical translations and closes with the discussion of current bottlenecks and an outlook for the coming years.
 
A successful regenerative medicine approach could solve organ shortage by providing biological substitutes for clinical use - clearly, this merits a collaborative effort.

Cuprins

Brain Central Neural System.- Vison system, retina, cornea.- Olfactory system.- Craniomaxillofacial bone engineering.- Ear, Nose and Throat.- Dental, tooth.- Thymus,  Lymphoid.- Oesophagus, Trachea.- Lung.- Gastro Intestinal Tract (Organoids).- Kidney.- Bladder/Urethra.- Liver (Biomaterial, Cells).- Endocrine Organs (Pancreas).- Salivary grand.- Breast Tissue / Fat Tissue.- Ovary.- Penis.- Great Vessels.- Cell sheets for cardiac tissue engineering.- Heart valve Bioengineering.- Ligament.- Meniskus als muskuloskelettaler Abschnitt.- Tendons.- Skeletal system and Muscle.

Notă biografică

Daniel Eberli is a scientific physician working in the translational field of urologic tissue engineering. He has a medical degree from the Medical School in Zurich, Switzerland, and a Ph.D. in Molecular Medicine from Wake Forest University, Winston Salem, NC. He has a faculty position at the Department of Urology at the University Hospital Zurich, where he devotes half of his time to patient care. Together with his research team, he is working on novel biomaterials for bladder reconstruction, improving autonomic innervation, cellular treatment of incontinence and tracking of stem cells.Sang Jin Lee, Ph.D., is currently a tenured associate professor at Wake Forest Institute for Regenerative Medicine (WFIRM), Wake Forest School of Medicine. Dr. Lee received his Ph.D. in chemical engineering from Hanyang University, Seoul, Korea, in 2003 and took a postdoctoral fellowship in the Laboratories for Tissue Engineering and Cellular Therapeutics at Harvard Medical Schooland Children’s Hospital Boston and the WFIRM, where he is currently a faculty member. He is also cross-appointed to the Virginia Tech–WFU Biomedical Engineering and Science. Dr. Lee has authored more than 140 scientific publications and reviews, has edited 2 textbooks, and has written 34 chapters in several books. Dr. Lee has an ix extensive knowledge and experience in biomaterials science, especially, biodegradable polymers and tunable hydrogels, with specific training and expertise in key research areas for tissue engineering and regenerative medicine. His research team has developed various biomaterial systems that improve cellular interactions by providing appropriate environmental cues. These biomaterial systems consist of drug/protein delivery system, nano/micro-scaled topographical feature, and hybrid materials that can actively participate in functional tissue regeneration. Recently, his team is utilizing automated 3D bioprinting technology to manufacture complex, multicellularliving tissue constructs that mimic the structure of native tissues. This can be accomplished by optimizing the formulation of biomaterials to serve as bioinks for 3D bioprinting, and by providing the biological microenvironment needed for the successful delivery of cells and biomaterials to discrete locations within the 3D structure.

Sang Jin Lee, Ph.D., is currently a tenured associate professor at Wake Forest Institute for Regenerative Medicine (WFIRM), Wake Forest School of Medicine. Dr. Lee received his Ph.D. in chemical engineering from Hanyang University, Seoul, Korea, in 2003 and took a postdoctoral fellowship in the Laboratories for Tissue Engineering and Cellular Therapeutics at Harvard Medical School and Children’s Hospital Boston and the WFIRM, where he is currently a faculty member. He is also cross-appointed to the Virginia Tech–WFU Biomedical Engineering and Science. Dr. Lee has authored more than 140 scientific publications and reviews, has edited 2textbooks, and has written 34 chapters in several books. Dr. Lee has an ix extensive knowledge and experience in biomaterials science, especially, biodegradable polymers and tunable hydrogels, with specific training and expertise in key research areas for tissue engineering and regenerative medicine. His research team has developed various biomaterial systems that improve cellular interactions by providing appropriate environmental cues. These biomaterial systems consist of drug/protein delivery system, nano/micro-scaled topographical feature, and hybrid materials that can actively participate in functional tissue regeneration. Recently, his team is utilizing automated 3D bioprinting technology to manufacture complex, multicellular living tissue constructs that mimic the structure of native tissues. This can be accomplished by optimizing the formulation of biomaterials to serve as bioinks for 3D bioprinting, and by providing the biological microenvironment needed for the successful delivery of cells and biomaterials to discrete locations within the 3D structure.



Caracteristici

Provides a concise overview of organ tissue engineering Analyzes the current state, issues, and key challenges Details desired outcomes with a focus on functional readouts