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Cell Engineering and Regeneration de Jeffrey M. Gimble

Cell Engineering and Regeneration: Reference Series in Biomedical Engineering

Editat de Jeffrey M. Gimble, Darja Marolt Presen, Richard O. C. Oreffo, Susanne Wolbank, Heinz Redl
en Limba Engleză Hardback – 19 aug 2020

Destinat cercetătorilor avansați și specialiștilor din domeniul biotehnologiei, Cell Engineering and Regeneration reprezintă o resursă enciclopedică de 1200 de pagini care sintetizează stadiul actual al medicinei regenerative. Observăm o abordare riguroasă, care nu se limitează doar la aplicațiile clinice, ci ancorează ingineria tisulară în fundamentele embriologiei și studiilor de evoluție. În cadrul Reference Series in Biomedical Engineering, acest volum explorează diversitatea surselor celulare, de la condrocite și celule musculare până la celule stem derivate din placentă, lichid amniotic sau țesut adipos.

Descoperim aici o progresie logică a conținutului, structurată pe patru piloni esențiali: sursele de izolare, metodele de precondiționare (cum ar fi sortarea și agregarea), modulația prin factori epigenetici și micro-ARN, și, în final, rutele de administrare sistemică sau locală. Credem că valoarea adăugată a acestei ediții rezidă în detalierea mecanismelor de comunicare intercelulară și în monitorizarea comportamentului celulelor după transplant. Complementar volumului Bioreactor Systems for Tissue Engineering II de Cornelia Kasper, care se concentrează pe mediul controlat de cultivare, lucrarea editată de Jeffrey M. Gimble și echipa sa pune un accent mai mare pe biologia celulară fundamentală și pe dinamica regenerării endogene.

Această lucrare consolidează direcțiile de cercetare anterioare ale lui Jeffrey M. Gimble, cunoscut pentru volumul său Adipose-Derived Stem Cells, extinzând analiza de la celulele adipoase către o platformă tehnologică vastă ce include celule iPS și trans-diferențierea. Stilul este unul tehnic, bazat pe protocoale de izolare (enzimatice și non-enzimatice) și pe integrarea factorilor de mediu, oferind o perspectivă exhaustivă asupra modului în care celulele manipulate ex vivo interacționează cu organismul gazdă.

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Specificații

ISBN-13: 9783319088303
ISBN-10: 3319088300
Pagini: 1200
Ilustrații: XXVI, 800 p. 86 illus., 81 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 1.54 kg
Ediția:1st ed. 2020
Editura: Springer International Publishing
Colecția Springer
Seriile Reference Series in Biomedical Engineering, Tissue Engineering and Regeneration

Locul publicării:Cham, Switzerland

Public țintă

Research

De ce să citești această carte

Această lucrare este esențială pentru cercetătorii care au nevoie de un fundament teoretic și practic solid în manipularea celulelor stem și primare. Cititorul câștigă o înțelegere profundă a proceselor de precondiționare și livrare celulară, beneficiind de expertiza unor lideri în domeniu. Este un ghid complet care transformă biologia teoretică în soluții aplicate pentru regenerarea organelor și țesuturilor afectate.

Despre autor

Jeffrey M. Gimble este un cercetător de renume în domeniul celulelor stem, cu o experiență vastă în studiul celulelor stromale derivate din țesut adipos (ASC). Lucrările sale anterioare au pus bazele utilizării acestor celule în diverse discipline științifice și clinice. Alături de co-editori precum Heinz Redl și Susanne Wolbank, acesta coordonează proiecte de anvergură în cadrul institutelor de traumatologie și regenerare tisulară. Expertiza sa colectivă se reflectă în rigoarea științifică a acestui volum, care integrează biotehnologia cu medicina clinică pentru a avansa soluțiile de terapie celulară.

Descriere scurtă

This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.

Cuprins

From the Contents: Sources.- Primary cells.- Chondrocytes.- Muscle cells.- ß-cells.- Schwann cells.- Cell lines for test systems.- Immortalized primary cells.- STEM.- Bone marrow derived.- Placenta derived cells.- Amnion.- in toto.- Placenta / Chorion.- Cord/Wharton cells.- Amniotic fluid cells.

Notă biografică

Dr. Gimble is Co-founder and Chief Scientific Officer of LaCell LLC and Obatala Sciences Inc. For over 30 years, Dr. Gimble’s laboratory has focused on stromal/stem cells isolated from bone marrow and adipose tissue as a model system for differentiation, hematopoiesis, metabolism, and regenerative medicine. Over this period, he has held faculty appointments (full time or adjunct) at the Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Baylor College of Medicine, University of North Carolina Chapel Hill, Duke University Medical Center, Louisiana State University Health Sciences Center New Orleans, and Tulane University Center for Stem Cell Research and Regenerative Medicine. In addition, Dr. Gimble spent 4 years in the Research Triangle Park, NC, at Zen-Bio, Inc., a biotechnology company supplying human primary adipose-derived cells to the research community (1999–2000), and at Artecel Sciences, a tissue engineering company that he co-founded and helped lead as Chief Scientific Officer (2000–2003). 

Dr. Darja Marolt Presen completed her doctoral studies at the University of Ljubljana, Slovenia, and was a visiting Ph.D. student at the Massachusetts Institute of Technology, Boston, USA. She trained as a postdoctoral scientist at Columbia University, New York, USA, and was leading the bone regeneration group at the New York Stem Cell Foundation Research Institute, New York, USA. She is currently the principal investigator of the bone bioengineering and regeneration group at the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in Vienna, Austria. Her research in bone tissue engineering and regeneration was supported by fellowships and grants from the Republic of Slovenia, New York Stem Cell Foundation, FFG Austria, and European Commission (Horizon 2020).

Richard O. C. Oreffo is Professor of Musculoskeletal Science and Co-founder/Director of the Centre for Human Development, Stem Cells and Regeneration at the University of Southampton. He leads a multidisciplinary research group focused on developing strategies to repair bone and cartilage, with translation a key personal driver. To achieve these goals, he has brought together and developed teams of clinicians/life scientists over the last 20 years and trained 47 M.D./Ph.D. students to completion, to date. He has published more than 300 peer-reviewed paper including breakthrough publications on skeletal stem cells and nanotopography, bone regeneration, as well as epigenetics and holds 6 patents. Richard is Founder, Director, and CSO of Renovos Biologics Limited, a Fellow of the Institute of Biology, and in 2015 was awarded a Doctor of Science degree by the University of Oxford and elected a Fellow of International Orthopaedic Research (FIOR) in 2019.

Susanne Wolbank is Head of the Stem Cell Biology Lab and, since 2019, Deputy Director at the Ludwig Boltzmann for experimental and clinical traumatology, Vienna, Austria. She is a biotechnologist (University of Natural Resources and Applied Life Sciences, Vienna) and held a postdoc position at the Clinical Research Center, Karolinska Institutet, Stockholm, on in vitro and in vivo characterization of human embryonic stem cells. She now combines her technological background with her basics knowledge on stem cells to investigate cellular aspects of tissue engineering and regenerative medicine. Her main research interest lies in stem cells from human “waste materials” such as perinatal tissues or adipose tissue. Her work has focused on optimizing these therapeutically relevant cells from isolation to improving the mode of application by activation via shockwave, cell-free application, combination with suitable biomaterials, and characterizing these cells including their interaction with other regenerative cell types. She is the current General Secretary of the International Placenta Stem Cell Society (IPLASS).

Heinz Redl Ludwig Boltzmann Institute for Clinical and Experimental Traumatology.
Heinz Redl has a background in biochemistry with almost 40 years’ experience in trauma and regenerative medicine research. He was Director of the Ludwig Boltzmann Institute of Experimental and Clinical Traumatology within the main trauma research center of AUVA (1998–2019) representing 7 trauma and 4 rehabilitation centers and holds the position of Associated Professor at the Technical University Vienna, Institute for Chemical Engineering, plus adjunct Professor at the University of Texas, Medical Branch at Galveston and at the Medical University of Vienna. He coordinates the Austrian Cluster for Tissue Regeneration since 2006, which includes 28 work groups from academia with multiple research targets and 12 spin-off groups. To further enhance industry cooperation, he founded the company Trauma Care Consult in 1998, which specializes in preclinical research and assists product registration at FDA and EMA. In 2014 he co-founded the spin-off company Liporegena and in 2017 MorphoMed. Prof. Redl organized many conferences in the field of regenerative medicine such as the World Congress for Tissue Engineering and Regenerative Medicine (TERMIS 2012) and many annual workshops (Winterschool Radstadt and Wiggers Bernhard series). He holds positions in several societies, such as Past-Chair of TERMIS-EU, and he was awarded “International Fellow of Tissue Engineering & Tissue Regeneration” in 2015. He is Editor in Chief of the updatable book series Springer/TERMIS “Tissue Engineering and Regeneration.” His expertise includes experience in different fields of tissue regeneration, being a co-developer of the fibrin sealant system (>40 years), developing surgical devices in current clinical use, and several collaboration projects with major industry partners.

Caracteristici

Covers the use of autologous versus allogeneic cell sources Explores procedures for cell isolation and pre-conditioning Includes contributions from the TERMIS community Includes supplementary material: sn.pub/extras