Molecular Mechanisms of Desensitization to Signal Molecules: Nato ASI Subseries H:, cartea 6

Chemotaxis and Chemosensing.- Behavioral adaptation in prokaryotes.- Surface receptor mediated activation and adaptation of adenylate cyclase in Dictyostelium discoideum.- Adaptation of Dictyostelium discoideum cells to chemotactic signals.- Adaptation, periodic signalling, and receptor modification.- Adenylate Cyclase-Coupled Systems.- Glucagon desensitization of adenylate cyclase in hepatocytes: an action mediated by a distinct population of glucagon receptors coupled to stimulate inositol phospholipid metabolism.- Cellular adaptation to signal molecules: activation and interaction of different signal transduction systems.- Desensitization of the ?-adrenergic coupled adenylate cyclase. The ?-adrenergic receptor kinase phosphorylates agonist-occupied cyclase-coupled receptors.- Structural microheterogeneity of ß1-adrenoceptors in turkey erythrocytes and their functional consequences.- Adaptive response of beta-adrenergic sensitive adenylate cyclase system.- Hormone specific desensitization of Sertoli cell adenylate cyclase in a cell-free system.- Inositol Phospholipid-Coupled Systems.- Adaptations of receptor-dependent phosphatidylinositol 4,5-bisphosphate breakdown.- Cell responses to phosphoinositide-hydrolysing receptors: some potential sites of modulation.- The kinase C substrate protein B-50 and feedback control of synaptic signal transduction.- Retroinhibition of the calcium-phosphatidylinositol cascade by diacylglycerol in thyroid.- Visual Transduction.- Fast termination and adaptation processes in the cGMP cascade of visual transduction.- Phosphorylation of rhodopsin involved in terminating the visual response.- Ion Conductance.- Permeability control and desensitization by nicotinic acetylcholine receptors.- Cellular Systems.- Regulation of leukocyteresponses to chemoattractants: role of receptors, guanine nucleotide regulatory (N) proteins and phospholipase C.- Modulation of macrophage oxygen metabolism. Evidence for desensitization and activation of the cell response to environmental stimuli.- Antibody induced down regulation of membrane receptors in human diseases.- Concluding Remarks.