Even though transmitter release and re-uptake are very complementary and physically in close proximity, researchers usually focus on only one of these two aspects. This volume, however, covers both processes and brings together two major presynaptic events in transcellular communication. It comprises 24 chapters and is divided into two parts: Part I, Neurotransmitter Release, and Part II, Neurotransmitter Uptake. The included topics range from ultrastructure and molecular control mechanisms to pathophysiology of some diseased states. Neuronal as well as non-neuronal mechanisms are treated. The concluding chapter emphasizes the importance of interdisciplinary collaboration and provides a link between the events in the presynaptic terminal and behavior.