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Membrane Systems: For Bioartificial Organs and Regenerative Medicine

Autor Loredana De Bartolo, Efrem Curcio, Enrico Drioli
en Limba Engleză Electronic book text – 21 mai 2017
The worldwide demand for organ transplants exceeds available donor organs by far. Understanding and controlling membrane material biocompatibility and transport phenomena currently opens new opportunities for the improvement of artificial organs (e.g., hemodialysis devices, hemofilters, blood oxygenator, etc.) and the design of bioartificial organs such as the bioartificial liver or pancreas.
The book covers the design and development of membranes and devices to be used as bio/artificial organs and in vitro growth of human cells as tissue engineered constructs, describes clinical applications of various membrane devices, bioengineering principles, materials and designs used in bio/artificial organs, and reviews the concepts, cell techniques, membrane scaffold materials and applications of tissue engineering.
An invaluable resource to researchers, scientists and academics involved in the advancement of membrane bio/artificial organs and tissues!

 
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Specificații

ISBN-13: 9783110390889
ISBN-10: 3110390884
Pagini: 290
Editura: De Gruyter
Colecția De Gruyter
Locul publicării:Berlin/Boston

Notă biografică

Loredana De Bartolo, University of Calabria, Rende, Italy; Efrem Curcio, University of Calabria, Rende, Italy; Enrico Drioli, University of Calabria, Rende, Italy.

Descriere

The worldwide demand for organ transplants exceeds available donor organs by far. Understanding and controlling membrane material biocompatibility and transport phenomena currently opens new opportunities for the improvement of artificial organs (e.g., hemodialysis devices, hemofilters, blood oxygenator, etc.) and the design of bioartificial organs such as the bioartificial liver or pancreas.
The book covers the design and development of membranes and devices to be used as bio/artificial organs and in vitro growth of human cells as tissue engineered constructs, describes clinical applications of various membrane devices, bioengineering principles, materials and designs used in bio/artificial organs, and reviews the concepts, cell techniques, membrane scaffold materials and applications of tissue engineering.
An invaluable resource to researchers, scientists and academics involved in the advancement of membrane bio/artificial organs and tissues!

 

Cuprins

AD>1. Natural and Synthetic Membranes
Biomedical Polymers
Preparation Techniques
Membrane Configurations
Characterization of Membrane Properties
Sterilization Procedures
2. Basic Issues in Membrane Separation for Biomedical Devices
Driving Forces in Molecular Separation
Transport through Microporous Membranes
Transport through Dense Membranes
Performance Parameters
3. Membrane Artificial Organs
Bioengineering Principles
Hemodialyser
Hemofilters
Plasmafilters
Blood Oxygenator
4. Biocompatibility Assessment
Membrane Trombogenicity
Complement Activation
Activation of Leukocytes
Inflammation Reaction
Bioincompatibility Aspects
5. Engineering of Membrane Biohybrid Organs
Modelling of Mass Transfer
Computational Fluid Dynamics Analysis
Analysis of Metabolic Kinetics
Configuration of Membrane Devices
6. Membrane Biohybrid Organs
Design Concepts
Liver
Pancreas
Kidney
Lung
Cardio-vascular devices
7. Citocompatibility Assessment
Cell Response
Protein Adsorption
Cell-Membrane Interactions
Role of Membrane Properties on Cell Arrangement and Organization
Evaluation of Tissue Compatibility
8. Regulatory and Ethical Issues
Regulatory of Biomedical Membrane Devices
Ethical Issues