This two-volume set of CCIS 391 and CCIS 392 constitutes the refereed proceedings of the Fourth International Conference on Information Computing and Applications, ICICA 2013, held in Singapore, in August 2013. The 126 revised full papers presented in both volumes were carefully reviewed and selected from 665 submissions. The papers are organized in topical sections on Internet computing and applications; engineering management and applications; intelligent computing and applications; control engineering and applications; cloud and evolutionary computing; knowledge management and applications; computational statistics and applications.