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Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics de Hae Won Kim

Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Editat de Hae Won Kim, A. Gerson Greenburg
en Limba Engleză Hardback – 9 ian 2014
Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.
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Specificații

ISBN-13: 9783642407161
ISBN-10: 3642407161
Pagini: 500
Ilustrații: XXIII, 746 p. 130 illus., 77 illus. in color.
Dimensiuni: 155 x 235 x 45 mm
Greutate: 1.25 kg
Ediția:2013
Editura: Springer Berlin, Heidelberg
Colecția Springer
Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

Brief historical account of HBOC development.- Physiology of respiration.- Oxygen transport to tissues.- Pathophysiology of acute anemia.- Global blood safety and need for safe blood supply.- Blood transfusion and its limitations.- Scientific basis and design of HBOCs.- HBOCs: a regulatory perspective.- Current HBOC products in development.- Clinical indications and clinical trials of HBOCs.- HBOCs and adverse events observed in clinical trials.- HBOC-mediated vasoactivity and hypertension.- HBOC and oxygen and nitrogen radical mediated toxicity.- HBOCs and clinical laboratory interference.- Animal models for HBOC studies.- New emerging Technologies for universal RBCs.- Future prospects.

Textul de pe ultima copertă

Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.

Caracteristici

Focus on Hemoglobin-based oxygen carriers (HBOCs) Up to date information on progress of existing products, new emerging products/technologies In-depth treatise covering rationale, scientific and clinical basis, ideal characteristics of HBOCs, approaches to HBOC products, scale up and manufacturing, preclinical and clinical studies for safety and efficacy evaluations, current challenges and future directions Includes supplementary material: sn.pub/extras