Nazis sequestered for generations in South America have engineered an army of vampires in preparation for a war against the living. But the Protestant-helmed Hellsing Organization and the Iscariot Agency of the Catholic Church stand in their way. The rival factions' best hope against the armies of the undead is to join forces, but can the Holy Church ever align with a group that uses unholy creatures like Alucard, the mightiest vampire of all?