Cantitate/Preț
Produs
Total produse
Vezi coșul
GABAB Receptor de Giancarlo Colombo

GABAB Receptor: The Receptors

Editat de Giancarlo Colombo
en Limba Engleză Paperback – 19 sep 2025
This new edition presents an up-to-date, comprehensive overview of the GABAB receptor system, including a particular focus on the most recent therapeutic applications and potential. This receptor system has been implicated in several diseases and disorders, including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. The new edition is completely reworked and updated, featuring the latest pharmacological advances on baclofen and positive allosteric modulators.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (2) 91285 lei  43-57 zile
  Springer International Publishing – 14 iun 2018 91285 lei  43-57 zile
  Springer – 19 sep 2025 141209 lei  38-44 zile
Hardback (2) 87972 lei  38-44 zile
  Springer International Publishing – 28 dec 2016 87972 lei  38-44 zile
  Springer – 18 sep 2024 133621 lei  43-57 zile

Din seria The Receptors

Preț: 141209 lei

Preț vechi: 148641 lei
-5%

Puncte Express: 2118
Preț estimativ în valută:
249100€ • 29110$ • 21717£

Carte tipărită la comandă

Livrare economică 18-24 februarie

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783031671500
ISBN-10: 3031671503
Pagini: 364
Dimensiuni: 155 x 235 x 20 mm
Greutate: 0.55 kg
Ediția:Second Edition 2024
Editura: Springer
Seria The Receptors

Cuprins

1. Historical Perspectives on the GABAB Receptor.- Section 1. Chemistry.- 2. Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagonists.- 3. Chemistry of GABAB Receptor Ligands: Focus on Positive Allosteric Modulators.- Section 2. Molecular Biology, Biochemistry, & Physiology.- 4. Molecular Structure and Trafficking of the GABAB Receptor.- 5. Distribution and Localization of the GABAB Receptor.- 6. Activation Mechanism and Allosteric Properties of the GABAB Receptor.- 7. Modulation of Neurotransmission by the GABAB Receptor.- 8. GABAB Receptor Functions In The Mesolimbic Dopamine System.- Section 3. Pharmacology.- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands.- 10. Targeting the GABAB Receptor for the Treatment of Epilepsy.- 11. Targeting the GABAB Receptor for the Treatment of Pain.- 12. Targeting the GABAB Receptor for the Treatment of Psychiatric Disorders.- 13. Targeting the GABAB Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders.- 14. Targeting the GABAB Receptor for the Treatment of Substance Use Disorder.- 15. Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder.- 16. Targeting GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough.- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABAB Receptor Agonist.- 18. Allosteric Modulators: The New Generation of GABAB Receptor Ligands.- 19. GABAB Receptor Antagonists as Cognition Enhancers.

Notă biografică

Giancarlo Colombo is a researcher at the Neuroscience Institute, Section of Cagliari, National Research Council of Italy. He has previously worked at the Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA, and the Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
His research interest is primarily on neurobiology and pharmacology of alcohol use disorder, with focus on the role of GABAB receptor in the control of multiple alcohol-related behaviors and the development of GABAB receptor ligands as possible pharmacotherapies for alcohol use disorder.
He has published approximately 200 papers in peer-reviewed journals and about 20 book chapters. He serves on the editorial board of the journals Alcohol and Alcohol and Alcoholism.

Textul de pe ultima copertă

This new edition presents an up-to-date, comprehensive overview of the GABAB receptor system, including a particular focus on the most recent therapeutic applications and potential. This receptor system has been implicated in several diseases and disorders, including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. The new edition is completely reworked and updated, featuring the latest pharmacological advances on baclofen and positive allosteric modulators.

Caracteristici

Focuses on recent therapeutic applications and future potential for drug discovery Bench-to-bedside" translational approach Explores different perspectives from various fields of study including medical medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology Explores specific diseases and disorders in which GABAB receptors have been implicated recently