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Essential Concepts in Molecular Pathology de William B. Coleman

Essential Concepts in Molecular Pathology

Editat de William B. Coleman, Gregory J. Tsongalis
en Limba Engleză Hardback – 16 feb 2010

Sub coordonarea editorilor William B. Coleman și Gregory J. Tsongalis, personalități marcante în cercetarea biomedicală, Essential Concepts in Molecular Pathology se impune ca o resursă academică riguroasă, menită să pună în dialog patologia tradițională cu descoperirile geneticii moderne. Putem afirma că lucrarea nu este doar o simplă sinteză, ci o recalibrare a materialului vast din ediția mamă, Molecular Pathology, fiind adaptată special pentru studenții la medicină și rezidenții care au nevoie de o bază conceptuală solidă fără a parcurge un tratat enciclopedic. Cartea extinde cadrul propus de Principles of Molecular Pathology cu date noi despre genomul și epigenomul uman, oferind o perspectivă de biologie integrativă a sistemelor.

Notăm cu interes modul în care autorii poziționează această lucrare în raport cu proiectele lor anterioare, precum The Molecular Basis of Human Cancer sau Molecular Diagnostics. Dacă acelea se concentrau pe nișe specifice (oncologie sau tehnici de laborator), volumul de față servește drept punte de legătură, explicând cum mecanismele moleculare dictează manifestările clinice vizibile în histopatologie. Structura este bicefală: prima parte analizează procesele fundamentale precum inflamația și neoplazia, în timp ce a doua parte plonjează în arhitectura moleculară a transcriptomului și a variațiilor genetice.

Experiența de parcurgere este facilitată de o organizare extrem de logică, unde fiecare capitol se încheie cu puncte de sumar ce fixează conceptele-cheie. Stilul este unul tehnic, precis, eliminând redundanțele pentru a lăsa loc explicațiilor despre medicina personalizată și diagnosticarea moleculară. Față de Pathology: A Modern Case Study, care mizează pe studii de caz, acest manual preferă o abordare sistematică a principiilor, fiind ideal pentru curriculumul universitar care vizează înțelegerea cauzalității bolilor la nivel celular.

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Specificații

ISBN-13: 9780123744180
ISBN-10: 0123744180
Pagini: 462
Ilustrații: illustrations
Dimensiuni: 216 x 276 x 34 mm
Greutate: 1.55 kg
Editura: ELSEVIER SCIENCE
Locul publicării:Amsterdam, Netherlands, Netherlands

Public țintă

Medical students, graduate students in allied health programs, undergraduate students; pathology residents and other postdoctoral residents and fellows interested in the molecular mechanisms of disease.

De ce să citești această carte

Recomandăm această carte studenților și rezidenților care doresc să înțeleagă biologia din spatele fiziopatologiei. Este un text esențializat care face legătura între patologia clasică și medicina de precizie. Cititorul câștigă o înțelegere clară a modului în care genomica și epigenomica transformă diagnosticul modern, beneficiind de un format structurat pentru învățare rapidă și eficientă, fără a sacrifica rigoarea științifică a editurii ELSEVIER SCIENCE.

Descriere scurtă

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.

  • Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease
  • Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
  • In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
  • "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
  • Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
  • Each chapter ends with Key Summary Points and Suggested Readings

Cuprins

PART I Essential Pathology - Mechanisms of Disease
1 Cell Injury, Cell Death, and Cellular Adaptation
John J. Lemasters, M.D., Ph.D.
2 Acute and Chronic Inflammation
Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.
3 Infection and Host Response
Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.
4 Neoplasia
William B. Coleman, Ph.D., and Tara Rubinas, M.D.

PART II Concepts in Molecular Biology and Genetics
5 Basic Concepts in Human Molecular Genetics
W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.
6 The Human Genome: Implications for the Understanding of Human Disease
William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.
7 The Human Transcriptome: Implications for the Understanding of Human Disease
Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.
8 The Human Epigenome: Implications for the Understanding of Human Disease
Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.
9 The Human Proteome: Implications for the Understanding of Human Disease
Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin
10 Integrative Systems Biology: Implications for the Understanding of Human Disease
M. Michael Barmada, Ph.D. and David C. Whitcomb

PART III Principles and Practice of Molecular Pathology
11 Pathology: The Clinical Description of Human Disease
William K. Funkhouser, M.D., Ph.D.
12 Molecular Pathogenesis: The Biological Basis of Human Disease
William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.
 13 Integration of Molecular and Cellular Pathogenesis
Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.

PART IV Molecular Pathology of Human Disease
14 Molecular Basis of Cardiovascular Disease
Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu
15 Molecular Basis of Hemostatic and Thrombotic Diseases
Nigel S. Key, M.D., and Alice Ma, M.D.
16 Molecular Basis of Lymphoid and Myeloid Diseases
Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.
17 Molecular Basis of Diseases of Immunity
David O. Beenhouwer, Ph.D.
18 Molecular Basis of Pulmonary Disease
Dani S. Zander, M.D., and Carol Farver, M.D.
19 Molecular Basis of Diseases of the Gastrointestinal Tract
Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.
20 Molecular Basis of Liver Disease
Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.
21 Molecular Basis of Diseases of the Exocrine Pancreas
Markus M. Lerch, M.D.
22 Molecular Basis of Diseases of the Endocrine System
Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.
23 Molecular Basis of Gynecologic Diseases
Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.
24 Molecular Pathogenesis of Diseases of the Kidney
Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.
25 Molecular Basis of Prostate Disease
William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.
26 Molecular Basis of Breast Disease
Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard
Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium
27 Molecular Basis of Skin Disease
John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.
28 Molecular Basis of Diseases of the Nervous System
Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.
 
PART V Practice of Molecular Medicine
29 Molecular Diagnosis of Human Disease
Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.
30 Molecular Assessment of Human Disease in the Clinical Laboratory
Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.
31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease
Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.

Recenzii

"Essential Concepts in Molecular Pathology provides the reader with what is missing from most targeted introductions to pathology; the cell biology behind pathophysiology. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ; the text provides the student with the background necessary for the understanding of today’s advances in pathology and medicine. The book is compact, easy to follow, filled with useful tables and figures and deserves reading by students and professionals interested in the molecular basis of disease."--Howard Reisner PhD, Professor of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, North Carolina, USA

"Finally, a book that captures the real world environment of molecular diagnosis and pathology of a comprehensive range of diseases while establishing a foundation in the basics of molecular biology is available in Essential Concepts in Molecular Pathology! The clinical hospital laboratory has become a critical link in the rapidly changing way in which we diagnose disease with respect to molecular diagnostics. It has been challenging to embed the fundamentals of molecular diagnosis to students of clinical laboratory science (CLS) programs without a resource of the most current, state-of-the-art molecular foundations. Essential Concepts has not only offered an outstanding textbook to build future CLS practitioners, but it also represents an outstanding "working" resource for the established molecular pathologist and others involved biomedical research.  As the title states, the individual chapters relate the most important points about specific topics with excellent figures and examples while directing the user to Suggested Readings for more in-depth coverage. The editors have put together a wonderful resource for allied health programs and similar professionals to use as a textbook or as a companion to a more comprehensive molecular pathology offering."--Rodney E. Rohde, MS, SV, SM, MP (ASCP), Associate Professor, Texas State University-San Marcos, Clinical Laboratory Science, San Marcos, TX, USA