Cantitate/Preț
Produs
Total produse
Vezi coșul
DNA Methyltransferases - Role and Function de Albert Jeltsch

DNA Methyltransferases - Role and Function: Advances in Experimental Medicine and Biology, cartea 1389

Editat de Albert Jeltsch, Renata Z. Jurkowska
en Limba Engleză Paperback – 11 noi 2023
This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years.
Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. 
Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (2) 89753 lei  38-44 zile
  Springer International Publishing – 6 iul 2018 89753 lei  38-44 zile
  Springer International Publishing – 11 noi 2023 134533 lei  6-8 săpt.
Hardback (1) 135262 lei  6-8 săpt.
  Springer International Publishing – 10 noi 2022 135262 lei  6-8 săpt.

Din seria Advances in Experimental Medicine and Biology

  • 30% Clinical, Biological and Molecular Aspects of COVID-19
    Preț: 71650 lei
  • 9% Fungal Biofilms and related infections: Advances in Microbiology, Infectious Diseases and Public Health Volume 3
    Preț: 90058 lei
  • 15% Noncommunicable Diseases
    Preț: 61664 lei
  • 5% Advancements in Clinical Research
    Preț: 68809 lei
  • 5% Chemo Fog
    Preț: 105731 lei
  • 5% Respiratory Medicine and Science
    Preț: 68864 lei
  • 5% The Multiple Therapeutic Targets of A20
    Preț: 105750 lei
  • 5% Allergy and Respiration
    Preț: 99099 lei
  • 5% Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health
    Preț: 107060 lei
  • 5% Advances in Microbiology, Infectious Diseases and Public Health: Volume 16
    Preț: 86355 lei
  • 5% Pulmonary Function
    Preț: 68933 lei
  • 15% Pathophysiology of Respiration
    Preț: 61552 lei
  • 5% Advances in Respiratory Cancerogenesis
    Preț: 68774 lei
  • 5% Pulmonary Infection and Inflammation
    Preț: 68933 lei
  • 5% Respiratory Contagion
    Preț: 68953 lei
  • 5% Trim/Rbcc Proteins
    Preț: 105406 lei
  • 5% Respiratory Treatment and Prevention
    Preț: 68864 lei
  • 5% A Guide to Breast Cancer Research
    Preț: 138279 lei
  • 20% Translational Informatics in Smart Healthcare
    Preț: 111653 lei
  • 5% Personalised Medicine: Lessons from Neurodegeneration to Cancer
    Preț: 112505 lei
  • 5% Immune Metabolism in Health and Tumor
    Preț: 123836 lei
  • 5% Ambient Air Pollution and Health Impact in China
    Preț: 111942 lei
  • 5% Infectious Agents Associated Cancers: Epidemiology and Molecular Biology
    Preț: 105897 lei
  • 18% Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control
    Preț: 107997 lei
  • 5% Translational Research in Breast Cancer: Biomarker Diagnosis, Targeted Therapies and Approaches to Precision Medicine
    Preț: 137977 lei
  • 20% Healthcare and Big Data Management
    Preț: 100351 lei
  • 18% Transgenic Ascidians
    Preț: 90966 lei
  • 5% Chromosome Translocation
    Preț: 87521 lei
  • 18% Zic family: Evolution, Development and Disease
    Preț: 92045 lei
  • 18% Cellular and Molecular Toxicology of Nanoparticles
    Preț: 118764 lei
  • 5% Recombinant Antibodies for Infectious Diseases
    Preț: 118368 lei
  • 5% The Hair Fibre: Proteins, Structure and Development
    Preț: 124206 lei
  • 5% Obesity, Fatty Liver and Liver Cancer
    Preț: 105931 lei
  • 18% Biomimetic Medical Materials: From Nanotechnology to 3D Bioprinting
    Preț: 108878 lei
  • 5% Single Cell Biomedicine
    Preț: 111992 lei
  • 5% Arterial Chemoreceptors: New Directions and Translational Perspectives
    Preț: 136328 lei
  • 5% Drosophila Models for Human Diseases
    Preț: 125487 lei
  • 18% Novel Biomaterials for Regenerative Medicine
    Preț: 136249 lei
  • 18% Cutting-Edge Enabling Technologies for Regenerative Medicine
    Preț: 135794 lei
  • 18% Survival Strategies in Extreme Cold and Desiccation: Adaptation Mechanisms and Their Applications
    Preț: 119492 lei
  • 5% Biostatistics for Human Genetic Epidemiology
    Preț: 155564 lei
  • 5% Circular RNAs: Biogenesis and Functions
    Preț: 125437 lei
  • 18% Intelligent Orthopaedics: Artificial Intelligence and Smart Image-guided Technology for Orthopaedics
    Preț: 108117 lei
  • 5% Biological Mechanisms of Minimal Residual Disease and Systemic Cancer
    Preț: 105494 lei
  • 15% Integrative Structural Biology with Hybrid Methods
    Preț: 62477 lei
  • 5% Targeted Therapy of Colorectal Cancer Subtypes
    Preț: 105494 lei
  • 18% Biomedical Visualisation: Volume 1
    Preț: 90908 lei
  • 18% Diabetes Mellitus: A risk factor for Alzheimer's Disease
    Preț: 91513 lei
  • 5% Single Molecule and Single Cell Sequencing
    Preț: 111382 lei

Preț: 134533 lei

Preț vechi: 164065 lei
-18% Nou

Puncte Express: 2018
Preț estimativ în valută:
23805€ • 27953$ • 20895£

Carte tipărită la comandă

Livrare economică 27 ianuarie-10 februarie 26

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783031114564
ISBN-10: 3031114566
Ilustrații: IX, 562 p. 1 illus.
Dimensiuni: 178 x 254 mm
Greutate: 0.98 kg
Ediția:2nd ed. 2022
Editura: Springer International Publishing
Colecția Springer
Seria Advances in Experimental Medicine and Biology

Locul publicării:Cham, Switzerland

Cuprins

Chapter 1. Mechanisms and biological roles of DNA methyltransferases and DNA methylation – from past achievements to future challenges.-  Chapter 2.Bacterial DNA Methylation and Methylomes.- Chapter 3. ChapterDomain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.- Chapter 4. Enzymology of Mammalian DNA Methyltransferases.- Chapter 5. Genetic Studies on Mammalian DNA Methyltransferase.- Chapter 6. Structure and Mechanism of Plant DNA Methyltransferases.- Chapter 7. DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics.- Chapter 8. N6-Methyladenine: A Conserved and Dynamic DNA Mark.- Chapter 9. Pathways of DNA Demethylation.- Chapter 10. Structure and Function of TET Enzymes.- Chapter 11.Proteins That Read DNA Methylation.- Chapter 12. Recent advances on DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications.-Chapter 13. The Role of DNA Methylation in Cancer.- Chapter 14. DNMTs and DNA damage.- Chapter 15. Role of DNMTs in brain.- Chapter 16. Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.-Chapter 17. Inhibitors of DNA methylation.- Chapter 18. Rewriting DNA Methylation Signatures at Will: The Curable Genome Within Reach? .- Chapter 19. DNA Labeling Using DNA Methyltransferases.

Notă biografică

Prof. Albert Jeltsch is a biochemist who received his PhD in Biochemistry 1994 at the Medical University Hannover (Germany). After PostDoc and Assistant Professorship (2003) at Justus-Liebig University in Giessen, he was appointed as Associate Professor of Biochemistry at Jacobs University Bremen in 2003, where he became Full Professor of Biochemistry in 2006. Prof. Jeltsch moved to the University of Stuttgart in 2011, where he is heading the Department of Biochemistry at the Institute of Biochemistry and Technical Biochemistry. For more than 25 years, the group of Prof. Jeltsch is investigating the structure, mechanism and function of bacterial and mammalian DNA methyltransferases. They have long-standing expertise in the field of rational and evolutionary protein design of DNA interacting enzymes and in the design of chimeric methylation enzymes for epigenome editing and gene regulation in eukaryotic cells. In addition, they study the specificity and activity of protein lysine methyltransferases and methyllysine reading domains and the biological role of protein methylation in cells.
Dr Renata Jurkowska is a molecular biologist with general interests in epigenetics, stem cells and lung biology. She obtained her M.Sc. degree in Biotechnology at Warsaw University (Poland) and went on to complete her PhD in Biochemistry and two postdocs in Germany, where she investigated the specificity and molecular mechanism of mammalian DNA methyltransferases and other epigenetic enzymes for 10 years. In 2015, she joined BioMed X Innovation Center (Germany) as a Principal Investigator, where she worked at the interface between academia and industry, leading a biomedical preclinical project in the field of respiratory medicine and epigenetics. In September 2019 she was appointed Senior Lecturer in the School of Biosciences at Cardiff University, UK. Her current research focuses on understanding how epigenetic regulation drives cellular identity in the healthy lung and how dysregulation of epigenetic processes due to environmental insults contributes to the development of lung diseases. Her group uses epigenomics technologies in combination with molecular biology tools to advance the mechanistic understanding of lung diseases, identify epigenetic biomarkers for diagnosis, and devise novel epigenetic therapeutic strategies.

Textul de pe ultima copertă

This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years.
As the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. 
Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.

Caracteristici

2nd edition, extensively updated with novel findings from the past 6 years Discusses novel insights into structure and mechanism of DNA methyltransferases Highlights the newest technologies related to DNA methylation