Vivaldi's Muse explores the life of Annina Girò, Antonio Vivaldi's longtime protégée. Annina first falls under the spell of the fiery and intriguing prete rosso (red-haired priest) at a young age, when Vivaldi is resident composer at the court of Mantua, her hometown. Stifled by the problems of her dysfunctional family, she has long dreamed of pursuing operatic stardom, and her attraction to the enchanting Venetian maestro soon becomes inseparable from that dream.