Cantitate/Preț
Produs

Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B (Springer Theses)

De (autor)
Notă GoodReads:
en Limba Engleză Carte Hardback – 16 Jan 2012
In his thesis, Xiaoyu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiaoyu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
Citește tot Restrânge
Toate formatele și edițiile
Toate formatele și edițiile Preț Express
Carte Paperback (1) 47074 lei  Economic 36-50 zile +16593 lei  11-19 zile
  Springer – 22 Feb 2014 47074 lei  Economic 36-50 zile +16593 lei  11-19 zile
Carte Hardback (1) 53582 lei  Economic 10-16 zile +4482 lei  5-12 zile
  Springer – 16 Jan 2012 53582 lei  Economic 10-16 zile +4482 lei  5-12 zile

Din seria Springer Theses

Preț: 53582 lei

Preț vechi: 72407 lei
-26%

Puncte Express: 804

Preț estimativ în valută:
10805 12179$ 9627£

Carte disponibilă

Livrare economică 26 iunie-02 iulie
Livrare express 21-28 iunie pentru 5481 lei

Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783642271946
ISBN-10: 3642271944
Pagini: 290
Ilustrații: 303 schwarz-weiße und 5 farbige Abbildungen
Dimensiuni: 155 x 235 x 23 mm
Greutate: 0.48 kg
Ediția: 2012
Editura: Springer
Colecția Springer
Seria Springer Theses

Locul publicării: Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

Introduction.- Results and Discussion.- Conclusion.- Experimental Section.- References.- Appendix I.- Appendix II.

Textul de pe ultima copertă

In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.

Caracteristici

Nominated by the Chinese University of Hong Kong as an outstanding PhD thesis
Novel and useful methodology for synthesizing highly substituted cyclic peroxides
Extends the field of Pd-catalyzed reactions