In this issue of Neuroimaging Clinics, guest editors Drs. Bryan Lanzman and Tarik F. Massoud bring their considerable expertise to the topic of The Subarachnoid Space: Percutaneous Access for Diagnosis and Image-Guided Therapies. In this first-of-its-kind issue, top experts the field discuss a wide range of topics related to the subarachnoid space, including imaging anatomy, guided lumbar punctures, puncture complications, myelography, cisternography, and much more.