In this issue of PET Clinics, guest editors Drs. Stephen Hunt, Steven Feigenberg, and Charles B. Simone bring their considerable expertise to the topic of PET Applications in Interventional Oncology. This PET Clinics issue is the first to be devoted to interventional oncology, and offers expert articles on multiple uses of PET/CT in oncology, applications of FAPI-PET, ablation, sarcoma, and techniques in assessing efficacy of IR interventions.