Systems Biology: Methods in Molecular Biology, cartea 2745

Conceptual Challenges in the Theoretical Foundations of Systems Biology.- An Integrative Approach toward Biology, Organisms, and Cancer.- Conceptual Challenges of the Systemic Approach in Understanding Cell Differentiation.- A Primer on Mathematical Modeling in the Study of Organisms and their Parts.- The Search for System’s Parameters.- Inverse Problems in Systems Biology: A Critical Review.- Systems Biology Approach and Mathematical Modeling for Analyzing Phase-space Switch during Epithelial-mesenchymal Transition.- Parameters Estimation in Phase-space Landscape Reconstruction of Cell Fate; A Systems Biology Approach.- Complexity of Biochemical and Genetic Responses Reduced using Simple Theoretical Models.- Systems Biology Modelling of Non-linear Cancer Dynamics.- Endogenous Molecular-cellular Network Cancer Theory: A Systems Biology Approach.- A Network-based Integrative Workflow to Unravel Mechanisms Underlying Disease Progression.- Spatiotemporal Fluctuation Analysis of Molecular Diffusion Laws in Live-cell Membranes.- A Method for Cross-species Visualization and Analysis of RNA-sequence Data.- Multi Agent Simulations of Population Behavior (A Promising Tool for Systems Biology).- Metabolomics: Challenges and Opportunities in Systems Biology Studies.- Systems Biology-driven Hypotheses Tested In Vivo: The Need to Advancing Molecular Imaging Tools. 

This second edition volume expands on the previous edition with discussions of the latest advancements and methods used by scientists to study systems biology. The chapters in this book are organized into four parts. Part One looks at models in systems biology and parameters identification such as short peptide analysis, metastasis models, and metabolomics. Part Two covers computational methods in the study of organisms, and cancer non-linear dynamics. Part Three discusses critical transition states across Waddington’s like landscapes such as understanding cell differentiation through single-cell approaches and modeling mammary organogenesis from biological first principles. Part Four talks about specific fields of investigation including inborn errors of metabolism, system biology approach in epithelial-mesenchymal transition, and an approach to understanding how COVID-19 spreads in the population. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Inlcudes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts