This study makes substantial contributions to both the theoretical and computational treatment of information structure, with a specific focus on creating natural language processing applications such as multilingual machine translation systems. The present study first provides cross-linguistic findings in regards to information structure meanings and markings. Building upon such findings, the current model represents information structure within the HPSG/MRS framework using Individual Constraints. The primary goal of the present study is to create a multilingual grammar model of information structure for the LinGO Grammar Matrix system. The present study explores the construction of a grammar library for creating customized grammar incorporating information structure and illustrates how the information structure-based model improves performance of transfer-based machine translation. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.