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Signaling Pathways in Liver Diseases

Editat de Jean-Francois Dufour, Pierre-Alain Clavien
en Limba Engleză Hardback – 9 noi 2015
Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohatitis, cirrhosis and liver tumours, which has led in changes to the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: * Autophagy * Notch Pathway * PI3K/PTEN Signaling in Liver Diseases * Sirtuins * Hepcidin and Iron * Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis * Oxidative Stress and Signaling in the Liver Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom will provide write a clear yet comprehensive review of their chosen topic. Chapters will contain clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signalling Pathways in Liver Diseases 3E is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.
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Specificații

ISBN-13: 9781118663394
ISBN-10: 111866339X
Pagini: 520
Ilustrații: illustrations
Dimensiuni: 191 x 249 x 30 mm
Greutate: 1.27 kg
Ediția:3rd Revised edition
Editura: Wiley
Locul publicării:Chichester, United Kingdom

Public țintă

Primary market
Hepatologists, hepatology researchers
Secondary market
Liver surgeons, Gastroenterologists, Specialist GI/hepatology nurses

Descriere

Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases.

Cuprins

The Cell Types and the Matrix.- Hepatocytes.- Signaling Pathways in Biliary Epithelial Cells.- Stellate Cells.- Signaling Pathways in Liver Diseases Kupffer Cells.- Hepatic Sinusoidal Endothelial Cells.- Extracellular Matrix.- Platelets: A New Cell Type in Liver Physiology.- Immune Cell Communication and Signaling Systems in Liver Disease.- The Pathways.- Toll-Like Receptors.- TNF/TNF Receptors.- Fas/FasL.- Interferon Signaling.- NF-?B.- JNKs in liver diseases.- Insulin Pathway.- Role of PKB/Akt in Liver Diseases.- Targeting mTOR Signaling Pathways in Liver Disease.- AMP-Activated Protein Kinase in Liver.- ER Stress Signaling in Hepatic Injury.- PPAR?, A Key Regulator of Hepatic Energy Homeostasis in Health and Disease.- Bile Acids and Their Receptors.- Signaling Pathways in Liver Diseases: PXR and CAR.- p53.- The MYC Network and Cancer.- The WNT/?-Catenin Pathway.- Sonic Hedgehog Pathway.- Hypoxia-Inducible Factor-1 Signaling System.- VEGF Signaling.- Apoptosis and Mitochondria.- Calcium Signaling.- HBV Signaling.- Hepatitis C Virus and Insulin Signaling.- MicroRNAs.- Hepatic Clocks.

Textul de pe ultima copertă

Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate moreresearch and lead to better exchange between the laboratory, the clinical ward and the operation room.
 
 

Caracteristici

Completely revised second edition with focus on specific signaling in liver diseases World-renowned contributors provide comprehensive overview on recent progress in hepatology Important source of reference for literature and planning of trails Includes supplementary material: sn.pub/extras