Self-blame is an integral part of our lives. We often blame ourselves for our failings and experience familiar unpleasant emotions such as guilt, shame, regret, or remorse. Self-blame is also what we often aim for when we blame others: we want the people we blame to recognize their wrongdoing and blame themselves for it. Moreover, self-blame is typically considered a necessary condition for forgiveness. However, until now, self-blame has not been an integral part of the theoretical debate on moral responsibility. This volume presents twelve new essays by leading moral philosophers, who set out bold new theories of the nature and ethics of self-blame, and the interconnection between self-blame and moral responsibility. The essays cast new light on traditional problems in the debate on moral responsibility and open new, exciting avenues for research in moral philosophy, moral psychology and the philosophy of punishment.