Cantitate/Preț
Produs
Total produse
Vezi coșul
Psychiatric Disorders: Methods and Protocols de Firas H. Kobeissy

Psychiatric Disorders: Methods and Protocols: Methods in Molecular Biology, cartea 829

Editat de Firas H. Kobeissy
en Limba Engleză Hardback – 10 ian 2012

Subliniem utilitatea practică a volumului Psychiatric Disorders, o resursă tehnică esențială pentru cercetătorii care urmăresc transpunerea observațiilor clinice în protocoale de laborator reproductibile. Această a doua ediție, publicată sub egida Humana, nu se rezumă la o simplă actualizare, ci extinde cadrul teoretic prin introducerea unor metodologii de ultimă oră în genetica și epigenetica tulburărilor neuropsihiatrice. Structura modulară, împărțită în unsprezece secțiuni tematice, ghidează cititorul de la fundamentarea necesității modelelor animale până la profiluri moleculare complexe ale depresiei sau tulburărilor de comportament alimentar.

Considerăm că rigoarea seriei Methods in Molecular Biology este elementul distinctiv aici: fiecare capitol include liste precise de reactivi, instrucțiuni de lucru detaliate și, esențial pentru activitatea de laborator, secțiuni de depanare (troubleshooting) pentru evitarea erorilor comune. Apreciem în mod deosebit includerea unor modele noi, precum testul preferinței sociale vizuale pe peștele-zebră, care reflectă diversificarea metodelor de testare dincolo de rozătoarele clasice.

Acoperă aceeași arie tematică ca Modeling Neuropsychiatric Disorders in Laboratory Animals de Kurt Leroy Hoffman, dar cu o abordare mult mai axată pe protocolul de laborator și biologia moleculară, spre deosebire de accentul pe raționamentul comportamental al lucrării lui Hoffman. În contextul operei editorului Firas H. Kobeissy, acest volum completează expertiza sa documentată în Neuroproteomics și Injury Models of the Central Nervous System. Dacă lucrările anterioare se concentrau pe trauma fizică și biomarkeri, Psychiatric Disorders integrează aceste tehnici de analiză moleculară în studiul patologiilor psihiatrice complexe, oferind o viziune sistemică asupra creierului.

Citește tot Restrânge

Din seria Methods in Molecular Biology

Preț: 93773 lei

Preț vechi: 114357 lei
-18%

Puncte Express: 1407
Paperback (2) de la 69301 lei
Hardback (2) de la 93773 lei

Carte tipărită la comandă

Livrare economică 25 mai-08 iunie

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă

Specificații

ISBN-13: 9781617794575
ISBN-10: 1617794570
Pagini: 625
Ilustrații: XXI, 615 p.
Dimensiuni: 178 x 254 x 41 mm
Greutate: 1.31 kg
Ediția:2012
Editura: Humana Press Inc.
Colecția Humana
Seria Methods in Molecular Biology

Locul publicării:Totowa, NJ, United States

Public țintă

Professional/practitioner

De ce să citești această carte

Recomandăm această lucrare specialiștilor și doctoranzilor care au nevoie de protocoale de laborator validate pentru studiul bolilor neuropsihiatrice. Cititorul câștigă acces la metodologii precise pentru modelarea tulburărilor bipolare, a anxietății și a neurodegenerării, beneficiind de experiența unor cercetători consacrați în evitarea capcanelor experimentale. Este un instrument de lucru indispensabil pentru orice laborator axat pe neuroștiințe moleculare și comportamentale.

Descriere scurtă

New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art “Omics approaches” and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models.  As a part of the highly successful Methods in Molecular Biology™ series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
 
Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.

Cuprins

New Frontiers in Animal Research of Psychiatric Illness.- Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview.- Qualitative Vs. Quantitative Methods in Psychiatric Research.- Animal Models of Self-Injurious Behavior: An Overview.- Rodent Models of Adaptive Decision Making.- Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis.- Modeling Depression in Animal Models.- Behavioral Model for Assessing Cognitive Decline.- The Pemoline Model of Self-Injurious Behavior.- Modeling Risky Decision Making in Rodents.- Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes.- An Animal Model to Study the Molecular Basis of Tardive Dyskinesia.- Models of Chronic Alcohol Exposure and Dependence.- Rat Models of Prenatal and Adolescent Cannabis Exposure.- Modeling Nicotine Addiction in Rats.- Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal.- Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms.- Cocaine Self-Administration in Rats: Hold Down Procedures.- Cocaine Self-Administration in Rats: Discrete Trials Procedures.- Cocaine Self-Administration in Rats: Threshold Procedures.- Assessing Locomotor-Stimulating Effects of Cocaine in Rodents.- Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure.- Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight.- Animal Models of Overeating.- The Activity-Based Anorexia Mouse Model.- Dissociating Behavioral, Autonomic,and Neuroendocrine Effects of Androgen Steroids in Animal Models.- Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders.- Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines.- P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD).- Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure.- Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders.- ADHD Animal Model Characterization: Transcriptomics and Proteomics Analyses.- Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics.- Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research.- Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia.- Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations.- Data Mining in Psychiatric Research.

Recenzii

From the reviews:
“This is a comprehensive compilation of in vivo and in vitro neuropsychiatric research methods and protocols on animal models and cutting-edge techniques in the wide spectrum of psychiatric illnesses. … It is written for graduates, postdoctoral workers, and established scientists working on behavioral and molecular neuropsychiatric research. … The detailed methods and protocols make this a quality book for any researcher in the field of neuroscience and psychiatry.” (Valerie E. Mathis-Allen, Doody’s Book Reviews, May, 2012)

Caracteristici

Provides researchers and clinicians with clear methodologies for conducting translational bench-to-bedside studies through these detailed animal models Features practical and easy-to-use protocols that are ready for the lab Includes expert tips and concrete implementation advice to ensure successful results Includes supplementary material: sn.pub/extras