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Physiologically Based Pharmacokinetic (PBPK) Model ing and Simulations: Principles, Methods, and Appl ications in the Pharmaceutical Industry, 2nd Editi de SA Peters

Physiologically Based Pharmacokinetic (PBPK) Model ing and Simulations: Principles, Methods, and Appl ications in the Pharmaceutical Industry, 2nd Editi

Autor SA Peters
en Limba Engleză Hardback – 13 dec 2021
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry ist das einzige Buch seiner Art, das sich an die schnell wachsende Gemeinschaft der PBPK-Anwender richtet und in klaren, prägnanten Worten die Grundlagen darstellt. Durch die Verbindung von Theorie und Praxis wird in diesem Werk das unglaubliche Potenzial der PBPK-Modellierung für die Verbesserung der Entdeckung und Entwicklung von Arzneimitteln betrachtet. In der neuen Ausgabe wird der Schwerpunkt stärker auf Anwendungen und relevante Fallstudien gelegt. Außerdem gibt es eine begleitende Website mit Datensätzen, die viele der wichtigsten Entwicklungen im Bereich der PBPK-Modellierung und -Simulation seit der Veröffentlichung der ersten Ausgabe im Jahr 2012 abbilden.
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Specificații

ISBN-13: 9781119497684
ISBN-10: 111949768X
Pagini: 624
Dimensiuni: 152 x 229 x 34 mm
Greutate: 1.01 kg
Ediția:2nd Edition
Editura: Wiley
Locul publicării:Hoboken, United States

Descriere

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations

The first book dedicated to the emerging field of physiologically based pharmacokinetic modeling (PBPK)

Now in its second edition, Physiologically Based Pharmacokinetic (PBPK) Modelling and Simulations: Principles, Methods, and Applications in the Pharma Industry remains the premier reference book throughout the rapidly growing PBPK user community. Using clear and concise language, author Sheila Annie Peters connects theory with practice as she explores the vast potential of PBPK modeling for improving drug discovery and development.

This fully updated new edition covers key developments in the field of PBPK modelling and simulations that have emerged in recent years. A brand-new section provides case studies in different application areas of PBPK modelling, including drug-drug interaction, genetic polymorphism, renal impairment, and pediatric extrapolation. Additional chapters address topics such as model-informed drug development (MIDD) and expose readers to a wide range of current applications in the field. Throughout the book, substantially revised chapters simplify complex topics and offer a balanced view of both the opportunities and challenges of PBPK modelling. Providing timely and comprehensive coverage of one of the most exciting new areas of pharmaceutical science, this book:

  • Describes the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics
  • Features a wealth of new figures and case studies of the applications of PBPK modelling along the value chain in drug discovery and development
  • Reflects the latest regulatory guidelines on the reporting of PBPK modelling analysis
  • Includes access to a new companion website containing code, datasets, explanations of case examples in the text, and discussion of key developments in the field
  • Contains a brief overview of the field, end-of-chapter keywords for easy reference, and an extensive bibliography

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry, Second Edition is an indispensable ­single-volume resource for beginning and intermediate practitioners across the pharmaceutical sciences in both industry and academia.

Cuprins

Notă biografică

Sheila Annie Peters, PhD, is Head of Translational Quantitative Pharmacology at Merck Healthcare, Darmstadt, Germany. Previously, she was an Associate Principal Scientist for Discovery DMPK and Bioanalytical Chemistry at AstraZeneca and Principal Scientist at Cyprotex Discovery. She has lectured at the Regional Engineering College (Trichy, India) and University of Madras and Pondicherry University.