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Peptide Nucleic Acids de Peter E. Nielsen

Peptide Nucleic Acids: Methods in Molecular Biology, cartea 3052

Editat de Peter E. Nielsen
en Limba Engleză Hardback – 3 sep 2026
This detailed new edition complements the previous edition with updates and new chemistry, concepts, and applications in the study of peptide nucleic acids (PNAs). The focus is on in vivo properties, behavior, and innovative applications of PNA, while maintaining contributions on both chemistry and nucleic acid recognition. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, Peptide Nucleic Acids: Methods and Protocols, Fourth Edition aims to inspire discovery and pursuit of new exciting avenues in the broad area of “artificial DNA.”
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Specificații

ISBN-13: 9781071653678
ISBN-10: 1071653679
Pagini: 360
Dimensiuni: 183 x 260 x 25 mm
Greutate: 0.87 kg
Ediția:Fourth Edition 2026
Editura: Springer Us
Colecția Methods in Molecular Biology
Seria Methods in Molecular Biology

Cuprins

Peptide Nucleic Acid-Fluorescence In Situ Hybridization (PNA-FISH) for the Detection and Spatial Location of Microorganisms.- Peptide Nucleic Acids for MicroRNAs Targeting: Updates and Future Perspectives.- Sequence-Directed Transcriptional Silencing Using Gamma Peptide Nucleic Acids.- Tetrahydrofuran Peptide Nucleic Acids.- PNA-Encoded Synthesis (PES) and DNA Display of Small Molecule Libraries.- Synthesis of Pyrrolidinyl PNA and Its Site-Specific Labeling at Internal Positions by Click Chemistry.- Reactive Quantum Dot-Based FRET Systems for Target-Catalyzed Detection of RNA.- Near Infrared In Vivo Whole Body Fluorescence Imaging of Peptide Nucleic Acid.- Nucleobase-Modified Triplex-Forming Peptide Nucleic Acids for Sequence-Specific Recognition of Double-Stranded RNA and DNA.- Monomer Synthesis and On-Resin Chemical Functionalization of Gamma Peptide Nucleic Acid.- Linking Peptides and PNAs: Bioorthogonal Nitrile-Aminothiol Conjugation for Antimicrobial Applications.- Synthesis of Peptide Nucleic Acid-Zirconium Coordination Nanoparticles.- Mechanistic Studies of Antibacterial PNAs by RNA-Seq Analysis.- Synthesis of Hydroxamate-Type Siderophores and Their Conjugates with PNA for Evaluation of Iron Binding and Bacterial Uptake.- In Vitro Preclinical Evaluation of BPP-PNA Antisense Antibiotics: A Protocol for Efficacy, Safety, and Resistance Analysis.- Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis.- Structural and Physicochemical Optimization of Next-Generation Antisense Oligonucleotide with BROTHERS for Mitigating Off-Target Effects.- Carbohydrate Ligand-Mediated Precise Kidney Delivery of PNA.- Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimido-Thioether Linkage.

Recenzii

"The book, Peptide Nucleic Acid, provides an excellent introduction to pNA's...provides useful information for the readers in the development of delivery systems for bioactive macromolecules." -Pharmaceutical Research

Textul de pe ultima copertă

Peptide nucleic acid (PNA) technology continues to grow in importance throughout molecular biology, genetic diagnostics, and molecular medicine. In Peptide Nucleic Acids: Methods and Protocols, Peter Eigil Nielsen has assembled a critically evaluated collection of PNA protocols that are either already well established around the world, such as PCR-clamping and in situ hybridization, or that display promise of significant future impact. Basic methods for PNA oligomer synthesis and analysis have also been included. Written by experts with hands-on experience in the methods they describe, these readily reproducible protocols contain detailed step-by-step instructions, tips on avoiding pitfalls and on extending the method to other situations, and introductory material explaining the theory behind the process.
Up-to-date and highly practical, Peptide Nucleic Acids: Methods and Protocols provides for both novice and experienced researchers a thorough and easy introduction to the optimal use of today's PNA technology across a wide variety of fields, including molecular biology, medicinal chemistry, genetic diagnostics, and drug development.