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Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism: Current Topics in Microbiology and Immunology, cartea 374

Editat de Jean Pieters, John D. McKinney
en Limba Engleză Hardback – 27 dec 2013
Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms.
In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
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Specificații

ISBN-13: 9783642402319
ISBN-10: 3642402313
Pagini: 256
Ilustrații: VIII, 245 p. 22 illus., 11 illus. in color.
Dimensiuni: 155 x 235 x 19 mm
Greutate: 0.52 kg
Ediția:2013
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Current Topics in Microbiology and Immunology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

 Genetic Diversity in Mycobacterium tuberculosis
Sebastien Gagneux
 
DNA Metabolism in Mycobacterial Pathogenesis
Digby F. Warner, Tone Tønjum and Valerie Mizrahi
 
Molecular Biology of Drug Resistance in Mycobacterium tuberculosis
Tasha Smith, Kerstin A. Wolff, and Liem Nguyen
 
Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations
John D. Szumowski, Kristin N. Adams, Paul H. Edelstein, and Lalita Ramakrishnan
 
Getting Across the Cell Envelope: Mycobacterial Protein Secretion
Aniek D. van der Woude, Joen Luirink, and Wilbert Bitter
 
A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria
Giulia Manina and John D. McKinney
 
Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes
Sabine Ehrt and Kyu Rhee
 
Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis
Rajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters
 
Host-Pathogen Interactions During Mycobacterium tuberculosis Infections
Sarah Stanley and Jeffery S. Cox
 

Caracteristici

A stimulus for the further exploration of the intricate biology of Mycobacterium tuberculosis and its interaction with the host
Written by respected experts from different disciplines
Richly illustrated
Includes supplementary material: sn.pub/extras