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Orthopedic Stem Cell Surgery

Autor Jeffrey N. Weiss
en Limba Engleză Paperback – 27 iun 2021

În peisajul medicinei regenerative contemporane, Orthopedic Stem Cell Surgery se impune ca un ghid clinic riguros, axat pe tranziția de la cercetarea de laborator la aplicabilitatea chirurgicală. Notăm cu interes modul în care autorul Jeffrey N. Weiss reușește să sintetizeze protocoalele complexe de utilizare a celulelor stem mezenchimale, oferind medicilor un șablon procedural clar pentru implementarea acestor terapii în practica ortopedică. Ne-a atras atenția rigoarea cu care sunt analizate studiile aprobate de Institutional Review Board (IRB), asigurând un cadru etic și științific solid pentru o specialitate aflată în plină expansiune. Structura volumului este pragmatică, fiind împărțită în trei secțiuni ce abordează patologii cu incidență ridicată. Primele capitole explorează în detaliu reparația coafei rotatorilor prin augmentare cu celule stem derivate din măduva osoasă și țesut adipos microfragmentat, comparând eficacitatea acestora cu terapia prin exerciții. Ulterior, progresia narativă se mută către osteoartrita genunchiului, evaluând impactul injecțiilor autologe și rezultatele trialurilor multicentrice. Suntem de părere că această lucrare completează excelent bibliografia existentă. Clinicienii care folosesc Bone and Cartilage Regeneration de Phuc Van Pham ca referință generală vor găsi aici protocoale chirurgicale mult mai specifice și o orientare directă către implementarea în sala de operație. De asemenea, spre deosebire de Orthobiologics, care oferă o privire de ansamblu asupra produselor biologice, volumul de față se concentrează strict pe chirurgia celulelor stem, menținând continuitatea metodologică pe care Jeffrey N. Weiss a stabilit-o în lucrările sale anterioare, precum Neurologic Stem Cell Surgery sau studiile sale despre celulele stem oculare.

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Specificații

ISBN-13: 9783030733018
ISBN-10: 3030733017
Pagini: 312
Ilustrații: XVIII, 291 p.
Dimensiuni: 155 x 235 x 16 mm
Greutate: 0.53 kg
Ediția:1st ed. 2021
Editura: Springer
Locul publicării:Cham, Switzerland

De ce să citești această carte

Recomandăm această carte chirurgilor ortopezi care doresc să integreze terapiile celulare în practica lor curentă. Cititorul câștigă acces la o sinteză a trialurilor clinice mondiale și la protocoale IRB verificate, esențiale pentru siguranța pacientului. Este un instrument indispensabil pentru a înțelege diferențele dintre diversele surse de celule stem (măduvă vs. țesut adipos) în tratarea leziunilor de coafă rotatorie și a gonartrozei.


Despre autor

Jeffrey N. Weiss este un specialist recunoscut în domeniul chirurgiei cu celule stem, având o abordare multidisciplinară ce acoperă neurologia, oftalmologia și ortopedia. Autorul s-a remarcat prin publicarea unor compendii vaste de studii clinice înregistrate la ClinicalTrials.gov, concentrându-se pe transformarea datelor de cercetare în ghiduri de bune practici. Lucrările sale, precum Ocular Stem Cell Studies și volumele dedicate bolii Alzheimer sau degenerescenței maculare, reflectă un angajament constant față de medicina bazată pe dovezi și față de standardizarea procedurilor regenerative la nivel internațional.


Cuprins

Section 1.  Rotator Cuff Repair.- 1.  Mesenchymal Stem Cell Augmentation in Patients Undergoing Arthroscopic Rotator Cuff Repair.- 2. Bone Marrow Derived Stem Cells for the Treatment of Rotator Cuff Tears.- 3. Regenexx SD Versus Exercise Therapy for Rotator Cuff Tears.- 4. Safety and Efficacy of Adult Adipose-Derived Stem Cell Injection Into Partial Thickness Rotator Cuff.- 5.  Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial- 6. Clinical Study on Mesenchymal Stem Cells Used in the Reconstruction Surgery of the Supraspinatus.- 7.  Efficacy of Microfragmented Lipoaspirate Tissue in Arthroscopic Rotator Cuff Repair.- 8. Mesenchymal Stem Cells in Rotator Cuff Repair.- 9. Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells.- 10. Adipose-derived Mesenchymal Stem Cells in Osteoarthritis.- Section 2. Knee Osteoarthritis.- 11. Impact of Mesenchymal Stem Cells in Knee Osteoarthritis.- 12. Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES) .- 13.  Early Regenerative Intervention for Post-Traumatic Osteoarthritis  (ERIPTO) .- 14.  Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction.- 15. Open Ended Trocar vs. Fenestrated Blunt Trocar in Bone Marrow Aspirate for Osteoarthriti.- 16. The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis.- 17. A Disease-based Treatment Study for Diagnosed Osteoarthritis Utilizing Adipose-derived Regenerative Cells.- 18. Stem Cell and Growth Factor Injury and Arthritis Clinical Research Study.- 19. Adipose-derived Mesenchymal Stem Cells in Osteoarthritis.- 20. Wharton's Jelly-derived Mesenchymal Stem Cells in Osteoarthritis.- 21. A Study Evaluating the Efficacy of a Single Injection Autologous Adipose Derived Mesenchymal Stromal Cells in Patients With Knee Osteoarthritis (ADIPOA-2) .- 22. Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair (AURA).- 23. Subchondral and Intra-articular Application of Bone Marrow Concentrate for Knee Unicompartmental OA (Marrow Mule) .- 24. Treatment of Early Knee Osteoarthritis With Autologous Adipose-derived Mesenchymal Stem Cells.- 25. Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis.- 26. Very Small Embryonic-like Stem Cells for Knee Osteoarthritis.- 27. Allogenic Adipose Tissue-Derived Mesenchymal Progenitor Cells for the Treatment of Knee Osteoarthritis.- 28. Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells (GXCPC1) for Knee Osteoarthritis.- 29. Treatment of Knee Osteoarthritis With Autologous Adipose-derived Mesenchymal Stem Cells.- 30. Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis.-  31. Mesenchymal Stem Cell Transplantation for Osteoarthritis.-  32. Effectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury.- 33.. Adipose-derived Stem Cells (ADSCs) for Knee Osteoarthritis.- 34. Allogeneic Bone Marrow MSC Therapy for Knee Osteoarthritis.- 35. Evaluate Safety and Explore Efficacy of SMUP-IA-01 in Patients With Knee Osteoarthritis.- 36. Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects.- 37. Follow-up Study for Participants Jointstem Clinical Trial.- 38. A Phase 3 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis.- 39. Follow-up Safety and Efficacy Evaluation on Subjects Who Completed Phase I Clinical Trial.- 40. Clinical Study of Intra Articular Injection of Catholic MASTER Cell (Bone Marrow Derived Mesenchymal Stem Cell) in Knee Osteoarthritis (MSC-OA).- 41. Follow-up Study for Participants of Jointstem Phase 3 Clinical Trial.- 42. Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Compared to Negative Control After High Tibial Osteotomy in theOsteoarthritis Patients.- 43. Autologous Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis.- 44. The Safety/Efficacy of Human Umbilical Cord Mesenchymal Stem Cells Therapy for Patients With Osteoarthritis.- 45. WHARTON JELLY ORIGINATED MESENCHIAL STEM CELL in GONARTHROSIS (WHAMKO) .- 46. Use of Adipose Tissue Derived Mesenchymal Stem Cells for Knee Osteoarthrosis.- 47. Use of Wharton Jelly Derived Mesenchymal Stem Cells for Knee Osteoarthrosis.- 48. Effects of α MAT Versus Steroid Injection in Knee Osteoarthritis (STα MAT-knee Study) .- 49. Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord Blood for Osteoarthritis Management.- 50. Comparative Effectiveness of Arthroscopy and Non-Arthroscopy Using Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium for Osteoartrithis (OA) .- 51.  The Evaluation of Safety and Effectiveness of Intraarticular Administration of Autologous Stromal-Vascular Fraction of Adipose Tissue Cells for Treatment of KneeJoint Arthrosis.- 52. Efficacy of Bone-marrow-derived and Placenta-derived Multipotent Mesenchymal Stem / Stromal Cells for Osteoarthritis.- 53. Bone Marrow Versus Adipose Autologous Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis.- 54. BMAC Use With Labral Repair.- Section 3. Labral Repair.- 55.  BMAC Use With Labral Repair.
 
 
 
 
 
 
 
 
 
 
 
 
 
                                                                                                                
 

Notă biografică

Jeffrey N. Weiss, MD    The Healing Institute 
Margate, FL, USA


Jeffrey N. Weiss, MD is the former Chief of Retinal Surgery at the Joslin Diabetes Center in Boston, Faculty of Harvard Medical School, and Visiting Scientist at the Massachusetts Institute of Technology. He entered college at 16 years of age, and medical school at age 19 on full scholarships. While in medical school he obtained a degree in Electrical Engineering, Magna Cum Laude with distinction, and graduated from Medical School, Summa Cum Laude, at 23 years of age.
Dr. Weiss is the author of more than 100 publications, including 11 books, holds more than 20 U.S. and foreign patents, and has been a Reviewer for multiple scholarly journals. He has served as a Visiting Professor, performed surgery, and lectured nationally and internationally. Dr. Weiss is also the founder of two companies, Ocular Research Associates Inc., and Micron Ophthalmic, Inc. which have manufactured andsold Dr. Weiss’ inventions worldwide.
Dr. Weiss performed the first retinal stem cell surgery in the world in 2010 and is the Principal Investigator of The Stem Cell Ophthalmology Treatment Studies I/II, the largest retinal and optic nerve stem cell studies in the world, The Neurologic Stem Cell Treatment Study, The Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality Treatment Study, and The Alzheimer’s, Cognitive Impairment and Autism Treatment Study. The studies are Institutional Review Board (IRB) approved, registered with NIH and listed on ClinicalTrials.gov.
Dr. Weiss first visited Dubai in 2008, where equipment he had invented was being showcased at Arab Health, the second largest medical equipment meeting in the world. In 2015, he obtained a Dubai medical license and has been travelling to Dubai to examine patients, perform surgery and lecture. His work has been featured in all the major Dubai newspapers and television. He was a finalist for the United ArabEmirates HealthCare Award in 2018 and 2019.


Textul de pe ultima copertă

This book is a concise guide that provides an easy to follow template for other physicians to develop similar stem cell based treatments within their specialty. It identifies and summarizes the current world-wide orthopedic stem cell trials.  
 
Organized into three sections, Orthopedic Stem Cell Surgery presents clinical studies that examine the procedures for setting up and implementing stem cell surgery within the specialty of orthopedics. Chapters maintain an accessible narrative while also addressing complex studies related to orthopedic stem cell surgery. 
 
A sister text to the recently published, Retinal and Optic Nerve Stem Cell Surgery, and Neurologic Stem Cell Surgery this expertly written book examines critical  Institutional Review Board (IRB) approved studies.


Caracteristici

Provides an easy to follow template for introducing stem cell surgery into a variety of specialties Follows a handful of routine repairs and includes several studies, independently run for each procedure Based on results from 11 years of treating approximately 600 patients with stem cell therapy